Ledakrin

CAS 6514-85-8 MFCD06514858

化学结构图

6514-85-8
SMILES: C[NH+](C)CCC[NH2+]c1c2ccccc2nc2cccc([N+](=O)[O-])c12.[Cl-].[Cl-]

化学属性

Mol. Weight397.34
Mol. FormulaC18H20N4O2.2ClH

别名和识别编码

Wiswesser Line NotationT C666 BNJ GNW IM3N1&1 &GH 2
Chemical NameAcridine,9-((3-(dimethylamino)propyl)amino)-1-nitro-,dihydrochloride
Synonym 1,3-Propanediamine, N,N-dimethyl-N'-(1-nitro-9-acridinyl)-, 1-Nitro-9-(3-dimethylaminopropylamino)-acridine dihydrochloride C 283 C-283 C283 Ledakrin NSC 247561 Nitracrine Nitracrine dihydrochloride
CAS Number6514-85-8
PubChem Substance ID23015
InChIInChI=1S/C18H20N4O2.2ClH/c1-21(2)12-6-11-19-18-13-7-3-4-8-14(13)20-15-9-5-10-16(17(15)18)22(23)24;;/h3-5,7-10H,6,11-12H2,1-2H3,(H,19,20);2*1H
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

安全信息

RTECSAR9244000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25750 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   20,399,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   31,661,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Bird - pigeon
DOSE/DURATION           : 1010 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - nausea or vomiting
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   28,777,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 34050 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   AITEAT Archivum Immunologiae et Therapiae Experimentalis. (Ars Polona, POB
   1001, 00-068 Warsaw 1, Poland)  V.10-    1962-  Volume(issue)/page/year:
   20,39

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 600 ng/plate
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   31,661,1979

TYPE OF TEST            : Host-mediated assay
TEST SYSTEM             : Rodent - mouse Bacteria - Salmonella typhimurium
DOSE/DURATION           : 500 ug/kg
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   31,661,1979

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 2500 pg/plate
REFERENCE :
   PJPPAA Polish Journal of Pharmacology and Pharmacy.  (ARS Polona, POB 1001,
   00-068 Warsaw 1, Poland) V.25-    1973-  Volume(issue)/page/year:
   31,661,1979

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 130 nmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   49,311,1984

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human HeLa cell
DOSE/DURATION           : 250 nmol/L
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   49,311,1984

系列性分类

相关产品推荐