L-Cysteine hydrochloride monohydrate L-半胱氨酸盐酸盐一水合物

CAS 7048-04-6 MFCD00065606

化学结构图

7048-04-6
SMILES:

化学属性

Mol. FormulaC3H10ClNO3S
Mol. Weight175.63
TSCAYes
Melting Point175-178°C
Appearance 3.46mg/kg。 无色至白色柱状结晶或白色结晶性粉末，略有特殊性气味。熔点175℃。溶于水、醇、氨水和乙酸，不溶于苯、乙醚、丙酮、乙酸乙酯和四氯化碳。1%的水溶液Ph值为1.7。具有还原性，有抗氧化和防止非酶性褐变作用。小白鼠经口LD 50
SolubilityH2O: 1 M at 20 °C, clear, colorless
Refractive index6 ° (C=8, 1mol/L HCl)
Stability对光及空气敏感,易吸潮
Boiling Point293.9°C at 760 mmHg
Flash Point131.5°C

别名和识别编码

Chemical NameL-Cysteine hydrochloride monohydrate
MDL NumberMFCD00065606
CAS Number7048-04-6
EC Number200-157-7
Beilstein Registry Number5158059
Synonym L-Cysteine (hydrochloride hydrate) {LY} L-Cysteine (hydrochloride hydrate) {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Cysteine (hydrochloride hydrate) {} {} {} {} {} {} {} {} {}
Merck Number2781
PubChem Substance ID329767969
Chemical Name TranslationL-半胱氨酸盐酸盐一水合物
Reaxys-RN5158059
InChIKeyQIJRTFXNRTXDIP-JIZZDEOASA-N
LabNetwork Molecule IDLN00188177
Canonical SMILESN[C@@H](CS)C(O)=O.[H]Cl.[H]O[H]
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分类

  • {SNA} Amino Acids, Analytical/Chromatography, Core Bioreagents, Pharmacopoeia,
  • {SNA} Amino Acids, Analytical/Chromatography, Biochemicals and Reagents, Pharmacopoeia, Pharmacopoeia A-Z, Pharmacopoeial Amino Acids
  • {SNA} Analytical Standards, Chromatography, EP Standards, EP Standards C - D,
  • {SNA} Amino Aci

产品应用

  • 生化研究。钢铁原材料中的钙、镁测定。测定溶血素的还原剂。厌氧菌的生长培养和计数。

相关文献及参考

  • Beilstein:4,506
  • [1]. McGavigan AK, et al. L-cysteine suppresses ghrelin and reduces appetite in rodents and humans. Int J Obes (Lond). 2015 Mar;39(3):447-55.

安全信息

GHS Symbol
WGK Germany1
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
  • P332+P313
  • P305+P351+P338+P337+P313
  • P302+P350
  • P302+P352+P332+P313+P362+P364
Signal word
RTECSHA2285000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S37 Wear suitable gloves 戴适当手套；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition 2-8°C, sealed storage, away from moisture {LY} 2-8°C, sealed storage, away from moisture Air Sensitive Store at RT. {} {LY} 2-8°C, sealed storage, away from moisture {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, sealed storage, away from moisture {} {} {} {} {} {} {} {} {} {} {} {} {} {LY
Hazard Codes Xi

其他信息

  • 上游原料:氢硫酸 --> L-胱氨酸 --> L-半胱氨酸 --> 锡粒
  • 参考质量标准:FCC，1992 含量(减压干燥20h)/% 98～102 比旋光度α D 20 +4.5°～+7.0° 干燥失重(减压干燥20h)/% 8.5～12.0 灼烧残渣/% ≤0.2 胱氨酸及其他氨基酸试验 - 重金属(以Pb计)/% ≤0.002 砷(以As计)/% ≤0.00015 铵盐/% ≤0.03
  • 用途三:生化研究。钢铁原材料中的钙、镁测定。测定溶血素的还原剂。厌氧菌的生长培养和计数。 L-Cysteine Hydrochloride Monohydrate别名
  • 方法一:用盐酸加热水解头发6～8h，减压蒸出盐酸，用活性炭脱色、过滤，滤液用氨水中和后得L-胱氨酸粗结晶，然后用氨水重结晶得L-胱氨酸。再以L-胱氨酸为原料，经还原可得L-半胱氨酸，其方法有二。 锡粒还原法。 将L-胱氨酸溶解于稀盐酸，加入锡粒并升温回流还原反应2h，滤去还原液中剩余的锡粒，并用水稀释，然后通人硫化氢使其饱和；过滤，滤渣用少量水洗；合并洗液和滤液，经减压浓缩、冷却结晶、分离、干燥得L-半胱氨酸盐酸盐。 HOOCCH(NH2)CH2SSCH2CH(NH2)COOH+Sn[HCl,H2S→HSCH2CH（NH2）COOH·CHl 电解还原法 将L-胱氨酸和稀盐酸加入电解槽，搅拌溶解，并在50℃下电解；电解液通硫化氢数小时使之饱和；过滤，滤液加活性炭脱色，脱色液经减压浓缩、冷却结晶、分离、干燥得L-半胱氨酸盐酸盐，每吨产品消耗胱氨酸0.7t，盐酸1t。 HOOCCH(NH2)CH2SSCH2CH(NH2)COOH+HCl→HSCH2CH（NH2）COOH·CHl
  • 用途一:用作医药、食品、化妆品添加剂
  • Sigma Aldrich:7048-04-6(sigmaaldrich)
  • MOL 文件:7048-04-6.mol
  • L-盐酸半胱氨酸一水物价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62007534 L-半胱氨酸盐酸盐; (R)-2-氨基-3-巯基丙酸盐酸盐 25g 18元 2011/04/16 C0517 L-半胱氨酸盐酸盐一水合物 L-Cysteine Hydrochloride Monohydrate 500G 1540元 2011/04/16 C0517 L-半胱氨酸盐酸盐一水合物 L-Cysteine Hydrochloride Monohydrate 25G 206元
  • 用途二:作为面制品发酵促进剂，加速谷蛋白形成，防止老化。我国规定可用于发酵面制品，最大使用量0.06g/kg。
  • 下游产品:
  • 敏感性:Hygroscopic
  • TCI Shanghai:L-半胱氨酸盐酸盐,一水合物 L-Cysteine Hydrochloride Monohydrate,>;99.0%(T)(7048-04-6)
  • Alfa Aesar:L-巯基丙氨酸盐酸盐一水合物,99% L-Cysteine hydrochloride monohydrate, 99%(7048-04-6)
  • 有吸湿性。在空气中缓慢氧化和分解。溶于水、乙醇和丙酮。水溶液呈酸性。半数致死量(小鼠，腹腔)1250mg/kg。
  • F:3-10-23

系列性分类

  1. Application Areas 应用领域分类
  2. Drug Discovery 新药研发
  3. Pharmacopoeia 药典
  4. Pharmacopoeia A-Z - Pharmacopoeia
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Bioactive Small Molecules - Cell Biology
  4. CI-CY - Bioactive Small Molecules
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Pharmaceutical Standards - Chromatography
  5. Pharmaceutical Secondary Standards - Pharmaceutical Standards
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Amino Acid Derivatives 氨基酸及其衍生物
  5. Cysteine/Cystine - Amino Acid Derivatives
  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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