安全信息
RTECS | KJ4552000 |
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 105 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - muscle weakness
Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR.
(Ars Polona, POB
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : 760 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
REFERENCE :
HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978-
Volume(issue)/page/year: 55,527,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : 660 mg/kg
TOXIC EFFECTS :
Behavioral - muscle weakness
Behavioral - ataxia
Behavioral - muscle contraction or spasticity
REFERENCE :
HEPHD2 Handbook of Experimental Pharmacology. (Springer-Verlag,
Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.50- 1978-
Volume(issue)/page/year: 55,527,1980
TYPE OF TEST : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Human - child
DOSE/DURATION : 26 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
Behavioral - coma
Vascular - BP elevation not characterized in autonomic section
REFERENCE :
BMJOAE British Medical Journal. (British Medical Assoc., BMA House,
Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year:
2,260,1977