1,4,7,10-Tetraazacyclododecane 轮环藤宁

CAS 294-90-6 MFCD00066281

化学结构图

294-90-6
SMILES: C1CNCCNCCNCCN1

化学属性

Mol. FormulaC8H20N4
Mol. Weight172.27
Density0.874
Melting Point108-113°C
Boiling Point283.8°C at 760 mmHg

别名和识别编码

Chemical Name1,4,7,10-Tetraazacyclododecane
CAS Number294-90-6
Synonym Cyclen {LY} Cyclen cyclen tetraaza-12-crown-4 tris acetic acid-1,4,7,10-tetraazacyclododecane {} {LY} Cyclen {} {} {LY} Cyclen {} {} {} {LY} Cyclen {} {} {} {} {LY} Cyclen {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Cyclen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number425-450-9
Beilstein Registry Number606114
MDL NumberMFCD00066281
PubChem Substance ID64963
Reaxys-RN606114
Alfabeta NameTETRAAZACYCLODODECANE 14710-,,,
Chemical Name Translation轮环藤宁
LabNetwork Molecule IDLN00185654
InChIInChI=1S/C8H20N4/c1-2-10-5-6-12-8-7-11-4-3-9-1/h9-12H,1-8H2
Canonical SMILESC1CNCCNCCNCCN1
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分类

  • Pharmaceuticals
  • {SNA} Amine Monomers, Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Materials Science, Monomers, Polymer Science, Secondary Amines, Synthetic Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • {SNA} Amine Monomers, Chelation/Complexation Compounds, Chemical Synthesis, Crown Ethers, Monomers, Polymer Science, Secondary Amines, Synthetic Reagents, 材料科学

产品应用

  • Macrocyclic aza analogue of the crown ether 12-crown-4. Cyclen compounds are capable of selectively binding cations and are used as a ligand with chemicals used in MRI contrast (as well ass other imag

相关文献及参考

  • Merck: 14,10413
  • Merck: 14,10413 Beilstein:26(5)11,23
  • Jeon, J.W. et al.: Bioorg. Med. Chem., 11, 2901 (2003);

安全信息

Signal word Danger
GHS Symbol
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P317
  • P301+P330+P331
  • P302+P350
  • P302+P352
  • P302+P361+P354
  • P303+P361+P353
  • P304+P340
  • P305+P351+P338
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P313
  • P337+P313
  • P361 Remove/Take off immediately all contaminated clothing. 立即去除/脱掉所有被污染的衣服。
  • P361+P364
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H312
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H331 Toxic if inhaled 吸入中毒
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Hazard Codes 8 Xi
RTECSXA5253000
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves
Storage condition 2-8°C, protect from light, stored under nitrogen {LY} 2-8°C, protect from light, stored under nitrogen Refrigerator {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light, stored under nitrogen {} {} {} {} {} {} {} {} {
Warnings IRRITANT
UN Number 1759 3259
Packing GroupIII
Hazard Class8 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 388 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NATWAY Naturwissenschaften.  (Springer-Verlag, Heidelberger Platz 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.1-    1913-  Volume(issue)/page/year:
   70,201,1983

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 435 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique.
   (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France)
   V.9-    1974-  Volume(issue)/page/year: 19,425,1984

其他信息

  • F:3-9-34
  • 下游产品:
  • 上游原料:盐酸 --> 乙酸乙酯 --> 硫酸 --> 乙酸 --> 吡啶 --> 甲醇钠 --> 4-甲苯磺酰氯 --> 二乙醇胺 --> 异丙醚 --> 二乙烯三胺
  • TCI Shanghai:1,4,7,10-四氮杂环十二烷 1,4,7,10-Tetraazacyclododecane,>;96.0%(GC)(T)(294-90-6)
  • Sigma Aldrich:294-90-6(sigmaaldrich)
  • 存储注意事项:湿度敏感
  • MOL 文件:294-90-6.mol
  • Hazard Note:Irritant
  • 图谱信息:轮环藤宁(294-90-6)核磁图( 13 CNMR) 轮环藤宁(294-90-6)核磁图( 1 HNMR)
  • Acros Organics:1，4，7，10-四氮环十二烷(环楞胺) Cyclen, 97%(294-90-6)
  • 轮环藤宁价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 T1874 1,4,7,10-四氮杂环十二烷 1,4,7,10-Tetraazacyclododecane 1G 331元 2014/06/02 T1874 1,4,7,10-四氮杂环十二烷 1,4,7,10-Tetraazacyclododecane 5G 986元 2010/06/21 294322500 轮环藤宁 Cyclen 97% 250 MG 1322元
  • MSDS 信息:Cyclen(294-90-6).msds

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Others 其他杂环
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Chelation/Complexation Compounds - Synthetic Reagents
  4. Crown Ethers 环状冠醚
  1. Materials Science 材料科学
  2. Products for Polymer Science Research
  3. Monomers - Polymer Science
  4. Amine Monomers - Monomers
  5. Secondary Amines - Amine Monomers
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Chelation/Complexation Compounds
  4. Calixarenes 杯芳烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Monomers
  4. Amine Monomers
  5. Primary Amines
  1. Materials Science 材料科学
  2. Macrocycles for Host-Guest Chemistry

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