2'-Deoxythioguanosine 2-氨基-9-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-1,9-二氢-6H-嘌呤-6-硫酮

CAS 789-61-7 MFCD00672275

化学结构图

789-61-7
SMILES: Nc1nc2c(ncn2[C@H]2C[C@H](O)[C@@H](CO)O2)c(=S)[nH]1

化学属性

Mol. FormulaC10H13N5O3S
Mol. Weight283.31

别名和识别编码

Chemical Name2'-Deoxythioguanosine
CAS Number789-61-7
Synonym 6-Thio-2'-Deoxyguanosine {LY} 6-Thio-2'-Deoxyguanosine Guanosine, 2'-deoxy-6-thio- NCI-C01581 TGdR Thioguanine deoxyriboside beta-2'-Deoxythioguanosine beta-2'-deoxythioguanosine beta-2'-deoxythioguanosine mono-hydrate beta-Thioguanine deoxyriboside beta-thioguanine deoxyriboside {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {} {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {} {} {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {} {} {} {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thio-2'-Deoxyguanosine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 6-Thio-2'-Deo
Chemical Name Translation2-氨基-9-((2R,4S,5R)-4-羟基-5-(羟甲基)四氢呋喃-2-基)-1,9-二氢-6H-嘌呤-6-硫酮
InChIKeySCVJRXQHFJXZFZ-KVQBGUIXSA-N
Wiswesser Line NotationT56 BN DN FN HNJ GZ ISH D- BT5OTJ CQ DQ E1
Beilstein Registry Number1224220
PubChem Substance ID3000603
InChIInChI=1S/C10H13N5O3S/c11-10-13-8-7(9(19)14-10)12-3-15(8)6-1-4(17)5(2-16)18-6/h3-6,16-17H,1-2H2,(H3,11,13,14,19)/t4-,5+,6+/m0/s1
Canonical SMILESOC[C@@H]1[C@H](C[C@H](N2C=NC3=C2NC(N)=NC3=S)O1)O
MDL NumberMFCD00672275
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分类

  • Heterocycles
  • Inhibitors
  • Nucleotides
  • Bases & Related Reagents
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Guanosine (G837900) derivative with cancer chemotherapeutic properties. It is involved in the inhibition of human RNase H-mediated RNA cleavage from DNA-RNA duplexes via incorporation into DNA.

相关文献及参考

  • Momparler, R.L. et al.: Cancer Treat. Rep., 62, 135 (1978); Krynetskaia, N.F. et al.: Mol. Pharmacol., 56, 841 (1999);

安全信息

RTECSUP0750000
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

系列性分类

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