H-Arg(NO2)-OH N-硝基-L-精氨酸
CAS 2149-70-4 MFCD00007033
化学结构图
SMILES: N=C(NCCC[C@H](N)C(=O)O)N[N+](=O)[O-]
化学属性
| Mol. Formula | C6H13N5O4 |
|---|---|
| Mol. Weight | 219.20 |
| Melting Point | 257°C |
| Solubility | Soluble in 0.1N HCl (moderately), and water (5 mM). |
| Boiling Point | 462.4°C at 760 mmHg |
别名和识别编码
| Chemical Name | H-Arg(NO2)-OH |
|---|---|
| CAS Number | 2149-70-4 |
| Alfabeta Name | N~IMINONITROAMINOMETHYLORNITHINE ~L5[]()--- |
| MDL Number | MFCD00007033 |
| Synonym | Nomega-Nitro-L-arginine {LY} Nomega-Nitro-L-arginine {} {LY} Nomega-Nitro-L-arginine {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Nomega-Nitro-L-arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} |
| Beilstein Registry Number | 4(4)2649 |
| EC Number | 218-418-9 |
| PubChem Substance ID | 440005 |
| Reaxys-RN | 1728914 |
| Chemical Name Translation | N-硝基-L-精氨酸 |
| LabNetwork Molecule ID | LN00166260 |
| InChI | InChI=1S/C6H13N5O4/c7-4(5(12)13)2-1-3-9-6(8)10-11(14)15/h4H,1-3,7H2,(H,12,13)(H3,8,9,10)/t4-/m0/s1 |
| Canonical SMILES | N[C@@H](CCCNC(N[N+]([O-])=O)=N)C(O)=O |
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分类
- {SNA} Application Index, Biochemicals and Reagents, Cell Signaling Enzymes, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, L to O, N, NOS Inhibitors, Nitric Oxide Metabolism, Nitric Oxide Synthase, Nitric Oxide Synthase Regulators, Nitric Oxide and Cell Stress, Peptides and Proteins, Peptides for Cell Biology, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- {SA} Amino Acid Derivatives, Arginine, Chemical Biology, Chemical Synthesis, Peptide Chemistry
- {SNA} Application Index, Bioactive Small Molecule Alphabetical Index,
产品应用
- NO合成酶抑制剂
相关文献及参考
- Beilstein:4(4)2649
安全信息
- S22 Do not breathe dust 不要吸入粉尘；
- S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
其他信息
- TCI Shanghai:Nω-硝基-L-精氨酸 Nomega-Nitro-L-arginine,>;98.0%(T)(2149-70-4)
- 图谱信息:N'-硝基-L-精氨酸(2149-70-4)质谱(MS) N'-硝基-L-精氨酸(2149-70-4)红外图谱(IR1) N'-硝基-L-精氨酸(2149-70-4)红外图谱(IR2)
- Nω-Nitro-L-arginine displays potent inhibition of NOS with selectivity for NOS1 and NOS3 over NOS2. It has been observed to inhibit endothelial nitric oxide biosynthesis and decrease radical generation of peroxynitrite ions. Other inhibitory effects demonstrated in experiments include blocking brady-kinin-induced relaxation in dog coronary artery strips and suppressing morphine tolerance in mice. N G-Nitro-L-arginine causes significant vasoconstriction and is utilized in studying nitric oxide as a neuronal messenger.
- 用途一:NO合成酶抑制剂
- MOL 文件:2149-70-4.mol
- Sigma Aldrich:2149-70-4(sigmaaldrich)
- 比旋光度:23.5 ° (c=4, 2N HCl 24 °C)
- N'-硝基-L-精氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 N0660 Nω-硝基-L-精氨酸 Nomega-Nitro-L-arginine 5G 512元 2014/06/02 N0660 Nω-硝基-L-精氨酸 Nomega-Nitro-L-arginine 25G 1270元
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