Nitroguanidine 硝基胍

CAS 556-88-7 MFCD00007039

化学结构图

556-88-7
SMILES: N=C(N)N[N+](=O)[O-]

化学属性

Mol. FormulaNO2NHC(=NH)NH2
Mol. Weight104.07
Melting Point239 °C (dec.)(lit.)
Solubility溶于热水,不溶于冷水,微溶于乙醇,不溶于醚,易溶于碱液。
Density2.0

别名和识别编码

Chemical NameNitroguanidine (Wetted with up to 20% water)
CAS Number556-88-7
Alfabeta NameNITROGUANIDINE N-
MDL NumberMFCD00007039
Synonym 1-Nitroguanidine 1-nitro-guanidin 1-nitroguanidine 2-Nitroguanidine Guanidine, 1-nitro- Guanidine, 1-nitro- (wet) Guanidine, nitro- Guanidine,nitro- LABOTEST-BB LTBB000482 N''-Nitroguanidine N(Sup1)-Nitroguanidine N1-Nitroguanidine NIGU NITROGUANIDINE NITROGUANIDINE ALPHA-FORM NQ NSC 41036 Nitro-guanidin Nitroguanidine Picrite Picrite (propellant) Picrite (the explosive) Picrite、NQ、N1硝基胍、alpha-硝基胍 [Oxido(oxo)hydrazono]methanediamine alpha-Nitroguanidine beta-Nitroguanidine guanidine,1-nitro-(wet) n n(1)-nitroguanidine nitro-guanidin
PubChem Substance ID86287517
EC Number209-143-5
Beilstein Registry Number1756640
Chemical Name Translation硝基胍
Merck Number6607
Wiswesser Line NotationWNMYZUM
LabNetwork Molecule IDLN00159975
InChIInChI=1S/CH4N4O2/c2-1(3)4-5(6)7/h(H4,2,3,4)
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分类

  • Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks
  • {uni_hamburg} no charge; 1fragment
  • {Chemicalbook} 农药中间体: 杀虫剂中间体: 其他杀虫剂
  • {SNA} Building Blocks, Chemical Synthesis, Guanidines, Nitrogen Compounds, Organic Building Blocks

产品应用

  • 用于有机合成,制备氨基胍、药物乐可安等。

相关文献及参考

  • Merck:6607 Beilstein: 3,IV,249
  • Short: III/5a
  • Short: IV/20B
  • Merck:6607

安全信息

Warnings IRRITANT 危化品目录(2015) 危险化学品
GHS Symbol
WGK Germany1
Hazard statements
  • H201 Explosive; mass explosion hazard 爆炸品;大规模爆炸危险。
  • H228 Flammable solid 易燃固体
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes F;Xi F,Xi
RTECSMF4600000
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P230 Keep wetted with … 保持湿润
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P250 Do not subject to grinding/shock/…/friction. 不要受研磨/冲击/....../摩擦。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P304+P340
  • P305+P351+P338
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P332+P317
  • P337+P313
  • P337+P317
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P362+P364
  • P370+P380
  • P372 Explosion risk in case of fire. 在火中有灾爆炸的危险。
  • P373 DO NOT fight fire when fire reaches explosives. 火烧到爆炸物时,切勿救火。
  • P401 Store… 存储
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
  • S47 Keep at temperature not exceeding ... °C (to be specified by the manufacturer) 保持温度不超过……°C(由生产厂家指定);
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R5 Heating may cause an explosion 加热会引起爆炸
  • R11 Highly flammable 非常易燃
UN Number 1336 UN 1336 4.1/PG 1
Hazard Class1.1D
Storage condition 储存温度2-8℃
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3850 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(1),18,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 48 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   PCJOAU Pharmaceutical Chemistry Journal (English Translation).  Translation
   of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013)  No.1-
   1967-  Volume(issue)/page/year: 10,1504,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 3120 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(1),18,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10200 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 45(1),18,1980

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Fibroblast
DOSE/DURATION           : 4 gm/L/24H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,337,1977

其他信息

  • 方法二:由硝酸在硫酸存在下于20℃反应而得。在冷却搅拌的情况下,将硝酸胍小量地缓缓加入浓硫酸中,反应温度不超过20℃。加毕,放置,倒入冰水中析出硝基胍。然后过滤,用水洗去酸性,再从沸水中重结晶即得成品。收率70%以上。
  • 毒性分级:中毒
  • 可燃性危险特性:易燃固体; 受热分解有毒氧化氮气体
  • 用途二:本品为一种有机合成原料,在农药上作为吡虫啉、啶虫脒的中间体,用于合成下一步中间体N-硝基亚氨基咪唑烷,此外,它经还原可以制氨基胍,用于合成心绞痛药物乐可安等,也可用于炸药和无烟水药的配制。
  • 爆炸物危险特性:高热、震动、撞击、摩擦可爆
  • 急性毒性:口服- 大鼠 LD50:10200毫克/ 公斤; 口服- 小鼠 LD50: 3850 毫克/ 公斤
  • 上游原料:硝酸胍
  • 用途一:用作炸药
  • MOL 文件:556-88-7.mol
  • Sigma Aldrich:556-88-7(sigmaaldrich)
  • 用途三:用于有机合成,制备氨基胍、药物乐可安等。也可用于炸药和无烟火药的配制。
  • 方法一:其制备方法是硝酸胍在浓硫酸存在下脱水生成硝基胍。 将280g硝酸胍在搅拌下缓慢加入预先已冷却的250mL浓硫酸(相对密度为1.84)中,在加入过程中严格控制反应温度在20℃以下,全部加完后间断搅拌,直至均匀无晶体为止。随后倒入碎冰和水的混合物中,充分搅拌并过滤,水洗至中性,再经重结晶,即得到硝基胍。
  • 类别:爆炸物品
  • 灭火剂:雾状水、泡沫
  • 外观性质:白色针状结晶, 不吸湿, 在室温下不挥发。
  • 每升100℃热水中可溶82.5g,在25℃水中只溶4.4g。溶于热水,不溶于冷水,微溶于乙醇、丙酮,不溶于醚,易溶于碱液。
  • MSDS 信息:硝基胍(556-88-7).msds
  • 下游产品:吡虫啉 --> 1-(6-氯-3-吡啶基甲基)-N-硝基亚咪唑烷-2-基胺 --> 1-甲基-3-硝基-1-亚硝基胍 --> 2-硝基亚氨基咪唑烷 --> 3-甲基-1H-1,2,4-噻唑
  • 储运特性:轻装轻放; 库房通风、远离明火、高温、阳光; 与氧化剂、易燃物分开存放

系列性分类


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