TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 1,501,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al.,
   eds., Washington, DC, American Soc. for Microbiology, 1978
   Volume(issue)/page/year: 1,501,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38 mg/kg
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - excitement
   Musculoskeletal - changes in teeth and supporting structures
REFERENCE :
   CHTHBK Chemotherapy (Basel).  (S. Karger Pub., Inc., 79 Fifth Ave., New
   York, NY 10003) V.13-    1968-  Volume(issue)/page/year: 26,196,1980

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 28 mg/kg/2W-I
TOXIC EFFECTS :
   Brain and Coverings - changes in circulation (hemorrhage, thrombosis, etc.)
   Sense Organs and Special Senses (Eye) - visual field changes
   Behavioral - headache
REFERENCE :
   AIME

TYPE OF TEST            : TDLo - Lowest publis

TYPE OF TEST            : TDLo - Lowest published tox

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 3750 ug/L
REFERENCE :
   BCPHBM British Journal of Clinical Pharmacology.  (Blackwell Scientific Pub.
   Ltd., POB 88, Oxford, UK)  V.1-    1974-  Volume(issue)/page/year:
   16,127,1983

• P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
• P302+P352+P333+P313+P362+P364
• P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
• P201 Obtain special instructions before use. 使用前获取专门指示。
• P501 Dispose of contents/container to..… 处理内容物/容器.....
• P405 Store locked up. 上锁保管。
• P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
• P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
• P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
• P308+P313
• P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
• P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。

• H303 May be harmfully swallowed 吞食可能有害