• 原料直供
• 试剂商城
• 直接询价

分类

• {SNA} Analytical Standards, EP Standards, EP Standards A - B, Pharmacopeia Metrological Institutes Standards, 分析/色谱
• {SNA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Signaling and Neuroscience, Dopaminergics, Endo, Neuroscience, Neurotransmission, Neurotransmitters, Others, 细胞生物学
• {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards, Pharmacopeia Standards
• Pharmaceuticals
• {uni_hamburg} no charge; carbocycle; alicycle; large ring; fused rings; 6ring; 8ring; 2fragments; ionic
• {SNA} A-AM, Approved Therapeutics/Drug Candidates,

产品应用

• 多巴胺释放剂用于治疗帕金森病和药物引起的锥体外系反应。该品阻止病毒穿入宿主细胞，并影响病毒的脱壳，达到抑制病毒增殖作用。可促进多巴胺释放。

相关文献及参考

• Merck: 14,374
• Short: EINECS
• Short: III/35B
• Kirschbaum, J., et al.: Anal. Profiles Drug Subs., 12, 1 (1983),
• Vernier, V.G., et al; Toxicol. Appl. Pharmacol., 15, 642 (1969),

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 24 mg/kg/1D-I
TOXIC EFFECTS :
   Behavioral - hallucinations, distorted perceptions
   Behavioral - excitement
REFERENCE :
   AEMED3 Annals of Emergency Medicine.  (American College of Emergency
   Physicians, 1125 Executive Circle, Irving, TX 75038)
   Volume(issue)/page/year: 19,668,1990

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 37 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   15,642,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   15,642,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 19,164,1988

{hazard_

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1100 mg/kg
SEX/DURATION            : female 5 day(s) pre-mating
                          female 1-6 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - pre-implantation mortality (e.g. reduction in
   number of implants per female; total number of implants per corpora lutea)
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   17,272,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 720 mg/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 4,44,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 240 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   GNRIDX Gendai no Rinsho.  (Tokyo, Japan)  V.1-10, 1967-76(?).
   Volume(issue)/page/year: 3,782,1969

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE

其他信息

• 可燃性危险特性:燃烧产生有毒氮氧化物和氯化氢烟雾;食之: 幻想,兴高采烈,亢奋,梦幻
• MSDS 信息:1-Adamantanamine hydrochloride(665-66-7).msds
• Alfa Aesar:1-金刚胺盐酸盐,99% 1-Adamantanamine hydrochloride, 99%(665-66-7)
• 上游原料:盐酸 --> 溴 --> 三氯化铝 --> 尿素 --> 氯 --> 氢 --> 亚硫酸钠 --> 铝镍合金 --> 二聚环戊二烯 --> 1-金刚烷胺
• 易溶于水，微溶于乙醇，极微溶于丙酮，不溶于苯和乙醚。无臭，味苦。
• MOL 文件:665-66-7.mol
• Sigma Aldrich:665-66-7(sigmaaldrich)
• 毒性分级:中毒
• 用途二:抗病毒药，属窄谱类，仅用于防治A2型病毒引起的流行性感冒。该品阻止病毒穿入宿主细胞，并影响病毒的脱壳，达到抑制病毒增殖作用。该品作为抗震颤麻痹药。可促进多巴胺释放。
• 急性毒性:口服-大鼠 LD50: 800 毫克/公斤; 口服-小鼠 LD50: 700 毫克/公斤
• 图谱信息:盐酸金刚烷胺(665-66-7)红外图谱(IR1) 盐酸金刚烷胺(665-66-7)核磁图( 1 HNMR) 盐酸金刚烷胺(665-66-7)Raman光谱 盐酸金刚烷胺(665-66-7)核磁图( 13 CNMR) 盐酸金刚烷胺(665-66-7)红外图谱(IR2) 盐酸金刚烷胺(665-66-7)质谱(MS)
• 方法一:由金刚烷胺成盐，精制而得。在搪玻璃中加入金刚烷胺、蒸馏水及活性炭。加盐酸调节至pH至3-5，加热至70℃溶解脱色半小时，冷却至室温，过滤。滤液抽入减压浓缩罐，在(14.7kPa)浓缩至呈粥状，自然冷却，过滤。加丙酮浸泡翻洗至pH5左右，滤干，在70℃干燥，得金刚烷胺盐酸盐。
• 储运特性:通风低温干燥
• 用途一:用作抗病毒药
• 敏感性:Hygroscopic
• 海关编码:29213099
• 盐酸金刚烷胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L0210602 盐酸金刚烷胺 25g 557元 2011/08/23 U1018505 盐酸金刚烷胺 200mg 1990元 2011/04/16 A0588 1-金刚烷胺盐酸盐 1-Adamantanamine Hydrochloride 10G 324元
• TCI Shanghai:1-金刚烷胺盐酸盐 1-Adamantanamine Hydrochloride,>;99.0%(T)(665-66-7)
• Acros Organics:1-金刚烷胺盐酸盐 1-Adamantanamine hydrochloride, 99+%(665-66-7)
• 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
• 类别:有毒物品