Adenosine 5'-(hexahydrogen pentaphosphate), 5'.5'-ester with adenosine, pentasodium salt P1,P5-二(腺苷5′)五磷酸五钠盐
CAS 4097-04-5 MFCD00077718
化学结构图
SMILES: Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OP(=O)([O-])OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O)[C@@H]2O)[C@@H](O)[C@H]1O.[Na+].[Na+].[Na+].[Na+].[Na+]
化学属性
| Mol. Formula | C20H29N10O22P5· 5 Na |
|---|---|
| Mol. Weight | 1026.28 |
| Solubility | 水中溶解度：50 mg/mL，透明，略带黄色 |
别名和识别编码
| Chemical Name | P1,P5-Di(adenosine-5') pentaphosphate pentasodium salt >=95% (HPLC), powder |
|---|---|
| MDL Number | MFCD00077718 |
| CAS Number | 4097-04-5 |
| Synonym | A(5')P5(5')A Diadenosine pentaphosphate pentasodium salt P1,P5-Di(adenosine-5') pentaphosphate pentasodium salt P1,P5-二(腺苷5′)五磷酸五钠盐 |
| Beilstein Registry Number | 4949216 |
| EC Number | 223-852-7 |
| PubChem Substance ID | 16219241 |
| Chemical Name Translation | P1,P5-二(腺苷5′)五磷酸五钠盐 |
| InChIKey | NNMFUJJMJIYTSP-CSMIRWGRSA-I |
| LabNetwork Molecule ID | LN02127023 |
| InChI | InChI=1S/C20H29N10O22P5.5Na/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(47-19)1-45-53(35,36)49-55(39,40)51-57(43,44)52-56(41,42)50-54(37,38)46-2-8-12(32)14(34)20(48-8)30-6-28-10-16(22)24-4-26-18(10)30;;;;;/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H2,21,23,25)(H2,22,24,26);;;;;/q;5*+1/p-5/t7-,8-,11-,12-,13-,14-,19-,20-;;;;;/m1...../s1 |
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分类
- {SNA} Enzyme Inhibitors, Enzyme Inhibitors by Type, Substrate Analogs, 生化试剂, 酶、抑制剂和底物
- {SNA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Substrate Analogs, 酶、抑制剂和底物
- {SNA} Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Type, Enzymes, Inhibitors, and Substrates, Substrate Analogs
产品应用
- 一种二腺苷聚磷酸，储存在血小板分泌颗粒、嗜铬染色和神经细胞里。在释放进细胞外空间后，它会对靶组织产生各种生物学活性。在神经系统它通过各种嘌呤能受体起作用。在体外它能激活5′-核苷酸酶而抑制腺苷激酶活性。
相关文献及参考
- [2]. Jesús Pintor, et al. Presence of diadenosine polyphosphates in human tears. Pflugers Arch. 2002 Jan;443(3):432-6.
- [1]. L Giraldez, et al. Adenosine triphosphate and diadenosine pentaphosphate induce [Ca(2+)](i) increase in rat basal ganglia aminergic terminals. J Neurosci Res. 2001 Apr 15;64(2):174-82.
- [1]. L Giraldez, et al. Adenosine triphosphate and diadenosine pentaphosphate induce [Ca(2+)](i) increase in rat basal ganglia aminergic terminals. J Neurosci Res. 2001 Apr 15;64(2):174-82.
- [2]. Jesús Pintor, et al. Presence of diadenosine polyphosphates in human tears. Pflugers Arch. 2002 Jan;443(3):432-6.
安全信息
其他信息
- 水中溶解度：50 mg/mL，透明，略带黄色
- A diadenosine polyphosphate stored in secretory granules of chromaffin and neuronal cells and thrombocytes. After release into the extracellular space, the compound affects a variety of biological activities in a wide range of target tissues. In the nervous system it acts through various purinergic receptors. It also activates 5'-nucleotidase and inhibits adenosine kinase activity in vitro. Ap5A is metabolized by soluble enzymes in the blood plasma and by membrane-bound ectoenzymes of a number of cell types including endothelial and smooth muscle cells.
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