6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) 5-溴-6-(咪唑啉-2-基)氨基喹喔啉酒石酸盐
CAS 70359-46-5 MFCD07773086
化学结构图
SMILES: Brc1c(NC2=NCCN2)ccc2nccnc12.O=C(O)C(O)C(O)C(=O)O
化学属性
| Mol. Formula | C15H16BrN5O6 |
|---|---|
| Mol. Weight | 442 |
| Melting Point | 207-208 |
别名和识别编码
| Chemical Name | 6-Quinoxalinamine, 5-bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-, (2R,3R)-2,3-dihydroxybutanedioate (1:1) |
|---|---|
| CAS Number | 70359-46-5 |
| Synonym | 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline D-tartrate 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine L-Tartrate 5-bromo-6-(imidazolidinylideneamino)quinoxaline 5-bromo-6-(imidazolin-2-ylamino)quinoxaline AGN 190342 AGN-190342 AGN190342 Alphagan Alphagan P Ratio Brimonidine Sanrosa UK 14,304 UK 14,304 18 UK 14,304-18 UK 14,30418 UK 14,308 UK 14304 UK 14308 UK-14,304-18 UK-14,308 UK-14304 UK14,30418 UK14,308 UK14304 brimonidine brimonidine Purite brimonidine tartrate brimonidine tartrate (1:1) brimonidine tartrate (1:1), (S-(R*,R*))-isomer brimonidine tartrate, (R-(R*,R*))-isomer bromoxidine mirvaso ratio-Brimonidine |
| Chemical Name Translation | 5-溴-6-(咪唑啉-2-基)氨基喹喔啉酒石酸盐 |
| LabNetwork Molecule ID | LN01283196 |
| PubChem Substance ID | 54405 |
| InChI | InChI=1S/C11H10BrN5.C4H6O6/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8;5-1(3(7)8)2(6)4(9)10/h1-4H,5-6H2,(H2,15,16,17);1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1 |
| MDL Number | MFCD07773072 |
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信息真实价格透明
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分类
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- It is an ?2 receptor agonist. It is a drug used to treat glaucoma.
相关文献及参考
- [2]. Cambridge, D., UK-14,304, a potent and selective alpha2-agonist for the characterisation of alpha-adrenoceptor subtypes. Eur J Pharmacol, 1981. 72(4): p. 413-5.
- [3]. Chopin, P., F.C. Colpaert, and M. Marien, Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway. J Pharmacol Exp Ther, 1999. 288(2): p. 798-804.
- Cantor, L. B., Expert Opin. Pharmacother., 1, 815 (2000),
- Katz, L.J., et al.: Am. J. Ophthalmol., 127, 20 (1999),
- [1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity
- [1]. Andorn, A.C., M.A. Carlson, and R.C. Gilkeson, Specific [3H]UK 14,304 binding in human cortex occurs at multiple high affinity states with alpha 2-adrenergic selectivity and differing affinities for GTP. Life Sci, 1988. 43(22): p. 1805-12.
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H317 May cause an allergic skin reaction 可能导致皮肤过敏
- H319 Causes serious eye irritation 严重刺激眼睛
- H331 Toxic if inhaled 吸入中毒
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
- P301+P310
- P301+P312
- P302+P352
- P304+P340
- P304+P341
- P305+P351+P338
- P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P332+P313
- P333+P313
- P337+P313
- P342+P311
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
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