Dexchlorpheniramine Maleate S-(+)-马来酸氯苯那敏
CAS 2438-32-6 MFCD00079046
化学结构图
SMILES: CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1.O=C(O)C=CC(=O)O
化学属性
| Mol. Formula | C20H23ClN2O4 |
|---|---|
| Mol. Weight | 391 |
| Melting Point | 112-115 °C(lit.) |
别名和识别编码
| Chemical Name | Dexchlorpheniramine Maleate |
|---|---|
| CAS Number | 2438-32-6 |
| Synonym | ######## (+)-2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine maleate (+)-Chlorpheniramine maleate (S)-γ-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate salt Dexchloropheniramine maleate Dexchlorpheniramine maleate Dextrochlorpheniramine maleate Polaramin Polaramine maleate Poramine maleate S-(+)-Chlorpheniramine maleate S-(+)-Chlorpheniramine maleate salt [γ-(4-chlorophenyl)-pyridine-2-propyl](dimethyl)ammonium hydrogen (Z)-maleate chlormene chlorpheniramine maleate d-Chlorpheniramine maleate g-(4-chlorophenyl)-N,N-dimethyl-2-pyridine propanamine maleate γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine maleate 马来酸右氯苯那敏 |
| MDL Number | MFCD00079046 |
| EC Number | 219-450-6 |
| PubChem Substance ID | 5281070 |
| Chemical Name Translation | S-(+)-马来酸氯苯那敏 |
| Wiswesser Line Notation | T6NJ BYR DG&2N1&1 &QV1U1VQ -+ |
| LabNetwork Molecule ID | LN00244025 |
| InChI | InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-;/m0./s1 |
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分类
- {SNA} Antagonists, Approved Therapeutics/Drug Candidates, Bayer, Bioactive Small Molecules, Biochemicals and Reagents, C-CH, Cell Biology, Cell Signaling and Neuroscience, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Histaminergics, Histaminergics - Antagonists,
产品应用
- The S-enantiomer of Chlorpheniramine (C424300). Antihistaminic.
相关文献及参考
- Ishida, M., et al.: Int. J. Pharm., 359, 46 (2008),
- Short: IV/8A Title: Enthalpies of Fusion and Transition of Organic Compounds Author: Zhang, Z.-Y.; Frenkel, M.; March, K.N.; Wilhoit, R.C. Editor: Marsh, K.N. Source: Landolt-Börnstein, New Series Volume: IV/8A Year: 1995 Keyword: organic compounds; enthaly of fusion; melting point; phase transition ISBN: 3-540-58854-X ISBN: 978-3-540-58854-2 Internet Resource: DOI:10.1007/b55145 RefComment: VIII, 588 pages.
- Short: EINECS Title: EINECS (European Inventory of Existing Commercial Chemical Substances) Source: Official Journal of the European Communities Volume: C 146 A (15.06.1990) Page: 1 Year: 1990 Internet Resource: http://ecb.jrc.ec.europa.eu/esis/index.php?PGM=ein Publish_Date: 1990/06/15
安全信息
GHS Symbol
- P301+P310
- H301 Toxic if swallowed 吞食有毒
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 240 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Behavioral - convulsions or effect on seizure threshold REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 124,347,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 84 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs).
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 188 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 82 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,436,1995
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 133 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other
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