Acepromazine Maleate 马来酸乙酰丙嗪

CAS 3598-37-6 MFCD00082473

化学结构图

3598-37-6
SMILES: CC(=O)c1ccc2c(c1)N(CCCN(C)C)c1ccccc1S2.O=C(O)/C=C\C(=O)O

化学属性

Mol. FormulaC23H26N2O5S
Mol. Weight442.53
Melting Point135-136°C

别名和识别编码

Chemical NameAcepromazine Maleate
CAS Number3598-37-6
Synonym Acepromazine (maleate) Acepromazine Maleate Acepromazine maleate {} {} {} {} {} {} {} {} {} {} {} {LY} Acepromazine (maleate) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acepromazine (maleate) {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Acepromazine (maleate) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Acepromazine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Vetranquil {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00082473
EC Number222-748-9
Chemical Name Translation马来酸乙酰丙嗪
Wiswesser Line NotationT C666 BN ISJ B3N1&1 EV1 &OV1U1VO
PubChem Substance ID6420038
LabNetwork Molecule IDLN00342655
InChIInChI=1S/C19H22N2OS.C4H4O4/c1-14(22)15-9-10-19-17(13-15)21(12-6-11-20(2)3)16-7-4-5-8-18(16)23-19;5-3(6)1-2-4(7)8/h4-5,7-10,13H,6,11-12H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
Canonical SMILESCC(C(C=C1N2CCCN(C)C)=CC=C1SC3=C2C=CC=C3)=O.O=C(O)/C=C\C(O)=O
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分类

  • A-AM, Antagonists, Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience, Dopaminargics - Antagonists, Dopaminergics, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Kinase/Phosphatase Biology, Membrane Protein Biology Tools,

产品应用

  • A tranquilizer.

相关文献及参考

  • Wirth, W., et al.: Arch. Int. Pharmacodyn, 123, 78 (1959),
  • Dyson, H., et al.: Can.Vet. J., 33, 462 (1992),
  • Nogueira, R.B., et al., Effects of sedation with acepromazine maleate and buprenorphine hydrochloride on femoral artery blood flow in healthy dogs Res. Vet. Sci. 93(2) , 989-92, (2011)
  • Mouney, M.C., et al., Effects of acepromazine maleate or morphine on tear production before, during, and after sevoflurane anesthesia in dogs Am. J. Vet. Res. 72 , 1427-30, (2011)
  • Kamine, A., et al., Changes in blood glucose and insulin responses to intravenous glucose tolerance tests and blood biochemical values in adult female Japanese black bears (Ursus thiβnus japonicus). Jpn. J. Vet. Res. 60 , 5-13, (2012)
  • Zhang Y., et al, A previously unidentified acepromazine metabolite in humans: implications for the measurement of acepromazine in blood. Cancer Res. 14 , 567-575, (2009)
  • Davalos D., et al.,, Stable in vivo imaging of densely populated glia, axons and blood vessels in the mouse spinal cord using two-photon microscopy. J. Neurosci. Methods 1 , 1-7, (2008) 摘要
  • Merck 14 ,32

安全信息

GHS Symbol
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P310+P330
  • P301+P317
  • P302+P352
  • P304+P340
  • P304+P340+P312
  • P317
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P317
  • P362+P364
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
  • H312 Harmful in contact with skin 皮肤接触有害
  • H315 Causes skin irritation 会刺激皮肤
  • H332 Harmful if inhaled 吸入有害
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
WGK Germany1
RTECSOB2450000
Hazard Codes 6.1
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S22 Do not breathe dust 不要吸入粉尘；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
  • S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
Risk Statements
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R50/53
UN Number 2811 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Or

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 6250 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   AJEMEN American Journal of Emergency Medicine.  (WB Saunders, Philadelphia,
   PA)  V.1-    1983-  Volume(issue)/page/year: 11,247,1993

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 65 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   19,87,1962

{h

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 175 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 113,53,1957

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 95 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals",
   11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year:

Packing GroupIII
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature

系列性分类

  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Proteins and Derivatives - Biochemicals and Reagents
  4. Membrane Protein Biology Tools - Proteins and Derivatives
  5. GPCR Proteins, Modulators and Antibodies - Membrane Protein Biology Tools
  6. GPCR Modulators - GPCR Proteins, Modulators and Antibodies
  7. Dopaminargics - Antagonists - GPCR Modulators
  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Neuroscience - Cell Signaling and Neuroscience
  5. Neurotransmission - Neuroscience
  6. Neurotransmitters - Neurotransmission
  7. Dopaminergics - Neurotransmitters
  8. Antagonists - Dopaminergics

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