N-(2-Aminoethyl)Isoquinoline-5-Sulfonamide Hydrochloride N-(2-氨基乙基)异喹啉-5-磺酰胺盐酸盐

CAS 116970-50-4 MFCD00083242

化学结构图

116970-50-4
SMILES: Cl.NCCNS(=O)(=O)C1=CC=CC2=CN=CC=C21

化学属性

Mol. FormulaC11H13N3O2S.ClH
Mol. Weight287.79

别名和识别编码

Chemical NameN-(2-Aminoethyl)Isoquinoline-5-Sulfonamide Hydrochloride
CAS Number116970-50-4
Synonym H-9 N-(2-Aminoethyl)-5-isoquinolinesulfonamide monohydrochloride N-(2-Aminoethyl)-5-isoquinolinesulfonamide hydrochloride
MDL NumberMFCD00083242
Beilstein Registry Number6548866
PubChem Substance ID24845840
Chemical Name TranslationN-(2-氨基乙基)异喹啉-5-磺酰胺盐酸盐
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分类

  • Amines
  • Heterocycles
  • Inhibitors
  • Protein Kinase Inhibitors and Activators

产品应用

  • A potent competitive inhibitor of protein kinase C, cGMP-, and cAMP-dependent protein kinase with respect to ATP.

相关文献及参考

  • Hidaka, H., et al.: J. Biol. Chem., 260, 5, 2922 (1985),

安全信息

GHS Symbol
WGK Germany3
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H302 Harmful if swallowed 吞食有害
  • H319 Causes serious eye irritation 严重刺激眼睛
RTECSNX4897000
Signal word Warning
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #92-264030

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JKXXAF Japanese Kokai Tokyo Koho Patents.  (U.S. Patent and Trademark
   Office, Foreign Patents, Washington, DC 20231)  Volume(issue)/page/year:
   #92-264030

系列性分类

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