Morphinan-3,14-diol, 17-(cyclobutylmethyl)-

CAS 42408-82-2 MFCD00864249

化学结构图

42408-82-2
SMILES: O[C@@]12CCCC[C@]31CCN(CC1CCC1)[C@@H]2CC1C=CC(O)=CC3=1

化学属性

Mol. FormulaC21H29NO2
Mol. Weight327.51

别名和识别编码

Chemical NameMorphinan-3,14-diol, 17-(cyclobutylmethyl)-
CAS Number42408-82-2
Synonym (-)-Butorphanol (-)-17-(Cyclobutylmethyl)-3,14?- l-BC 2627 17-(Cyclobutylmethyl)morphinan-3,14-diol Butorphanol
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分类

  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Mixed opioid agonist-antagonist. Analgesic (narcotic); antitussive.

相关文献及参考

  • Vargas-Arreola, F., et al.: Curr. Ther. Res., 22, 186 (1977),
  • Heel, R.C., et al.: Drugs, 16, 473 (1978),

安全信息

RTECSQC7793000 
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraspinal
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 35 ug/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - local anesthetic
   Behavioral - excitement
   Cardiac - pulse rate increase, without fall in BP
REFERENCE :
   AACRAT Anesthesia and Analgesia (New York).  (Elsevier Science Pub. Co.,
   Inc., 52 Vanderbilt Ave., New York, NY 10017)  V.36-    1957-
   Volume(issue)/page/year: 64,452,1985

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