Benzoic acid,2-(8'-trifluoromethyl-4'-quinolylamino)-,2,3-dihydroxypropyl ester
CAS 23779-99-9 MFCD00864363
化学结构图
SMILES: OCC(O)COC(=O)C1C=CC=CC=1NC1C=CN=C2C(=CC=CC=12)C(F)(F)F
化学属性
| Mol. Formula | C20H17F3N2O4 |
|---|---|
| Mol. Weight | 406.39 |
别名和识别编码
| Chemical Name | Benzoic acid,2-(8'-trifluoromethyl-4'-quinolylamino)-,2,3-dihydroxypropyl ester |
|---|---|
| CAS Number | 23779-99-9 |
| Synonym | Diralgan 2-(8'-Trifluoromethyl-4'-quinolylamino)benzoic acid 2,3-dihydroxy propyl Floctafenine 8-Trifluoromethyl-7-deschloroglafenine R 4318 ######## 2,3-Dihydroxypropyl N-(8-(trifluoromethyl)-4-quinolyl)anthranilate Idarac RU 15750 4-(o-(2',3'-Dihydroxypropyloxycarbonyl)phenyl)-amino-8-trifluoromethylquinoline Novodolan |
| Wiswesser Line Notation | T66 BNJ JXFFF EMR BVO1YQ1Q |
| Beilstein Registry Number | 0457808 |
| Chemical Name Translation |
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分类
- Amines
- Aromatics
- Pharmaceuticals
- Intermediates & Fine Chemicals
产品应用
- Floctafenine is an nonsteroidal antiinflammatory drug (NSAID) used in inflammatory disorders.
相关文献及参考
- Tawakkol, M., et al.: Pharmazie, 36, 163 (1981),
- Sandouk, P., et al.: Ther. Drug Monit., 17, 544 (1995),
- Moussa, B., et al.: J. Pharm. Biomed. Anal., 23, 1045 (2000),
安全信息
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 535 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Gastrointestinal - ulceration or bleeding from stomach REFERENCE : YACHDS Yakuri
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1960 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - changes in motor activity (specific assay) Gastrointestinal - ulceration or bleeding from stomach REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 9(Suppl 2),299,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 250 mg/kg TOXIC EFFECTS : Behavioral - changes in motor activity (specific assay) Behavioral - coma Blood - hemorrhage REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 9(Suppl 2),299,1981
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 245 mg/kg TOXIC EFFECTS : Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea REFERENCE : TXAPA9 Toxicology and Ap
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 1300 mg/kg SEX/DURATION : female 6-18 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 9(Suppl 2),379,1981
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 700 mg/kg SEX/DURATION : female 1-7 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 9(Suppl 2),325,1981
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