Propionic acid,2-(p-(imidazo(1,2-a)pyridin-2-yl)phenyl)-

CAS 55843-86-2 MFCD00864366

化学结构图

55843-86-2
SMILES: CC(C(O)=O)C1C=CC(=CC=1)C1=CN2C=CC=CC2=N1

化学属性

Mol. FormulaC16H14N2O2
Mol. Weight266.32

别名和识别编码

Chemical NamePropionic acid,2-(p-(imidazo(1,2-a)pyridin-2-yl)phenyl)-
Wiswesser Line NotationT56 AN DNJ CR DY1&VQ
Synonym 4-Imidazo(1,2-a)pyridin-2-yl-alpha-methylbenzeneacetic acid 2-(p-(2-Imidazo(1,2-a)pyridiyl)phenyl)propionsaeure Y-9213 2-(p-(2-Imidazo(1,2-a)pyridyl)phenyl)propionic acid Propionic acid, 2-(4-(imidazo(1,2-a)pyridin-2-yl)phenyl)- Antopen 2-(4-(Imidazo(1,2-a)pyridin-2-yl)phenyl)propionic acid Miroprofen
Beilstein Registry Number0888858
CAS Number55843-86-2
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安全信息

RTECSUF4892000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 292 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - aplastic anemia
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 12,993,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 372 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - aplastic anemia
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 12,993,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 365 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - aplastic anemia
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   IYKEDH Iyakuhin Kenky

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 687 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Blood - aplastic anemia
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-c

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 675 mg/kg
SEX/DURATION            : female 17-22 day(s) after conception
                          lactating female 21 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - live birth index (measured after birth)
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 12,827,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 1300 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 12,808,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 11 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - physical
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 12,808,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 275 mg/kg
SEX/DURATION            : female 7-17 day(s) after conception

系列性分类

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