Prulifloxacin 普卢利沙星

CAS 123447-62-1 MFCD00864847

化学结构图

123447-62-1
SMILES: CC1OC(=O)OC=1CN1CCN(CC1)C1=CC2=C(C=C1F)C(=O)C(=C1SC(C)N21)C(O)=O

化学属性

Mol. FormulaC21H20FN3O6S
Mol. Weight461

别名和识别编码

Chemical NamePrulifloxacin
CAS Number123447-62-1
Synonym Prulifloxacin 6-Fluoro-1-methyl-7-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-1-piperazinyl]-4-oxo- NM 441
Chemical Name Translation普卢利沙星
Reaxys-RN5894071
MDL NumberMFCD00864847
PubChem Substance ID253660145
Merck Number7908
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Fluoroquinoline antibacterial; prodrug for active metabolite, Ulifloxacin. Antibacterial.

相关文献及参考

  • Ozaki, M., et al.: Antimicrob. Agents Chemother., 35, 2496 (1991),
  • Segawa, J., et al.: J. Med. Chem., 35, 4727 (1992),
  • Nakashima, M., et al.: J. Clin. Pharmacol., 34, 930 (1994),

安全信息

RTECSXJ0600000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 915 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Behavioral - ataxia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 21(Suppl
   1),33,1996

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 21(Suppl
   1),33,1996

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Gastrointestinal - nausea or vomiting
REFERENCE :
   JTSCDR Journal of Toxicological Sciences.  (Japanese Soc. of Toxicological
   Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku,
   Tokyo 113, Japan)  V.1-    1976-  Volume(issue)/page/year: 21(Suppl
   1),149,1996

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :

{hazard_

Storage condition <0°C

系列性分类

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