(6S,7R)-7-((R)-2-Amino-2-(4-Hydroxyphenyl)Acetamido)-8-Oxo-3-((E)-Prop-1-En-1-Yl)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid 头孢曲唑

CAS 92665-29-7 MFCD00865082

化学结构图

92665-29-7
SMILES: C/C=C/C1CS[C@@H]2[C@H](NC(=O)[C@H](N)C3C=CC(O)=CC=3)C(=O)N2C=1C(O)=O

化学属性

Mol. Weight407.48
Mol. FormulaC18H19N3O5S.H2O

别名和识别编码

CAS Number92665-29-7
Chemical Name(6S,7R)-7-((R)-2-Amino-2-(4-Hydroxyphenyl)Acetamido)-8-Oxo-3-((E)-Prop-1-En-1-Yl)-5-Thia-1-Azabicyclo[4.2.0]Oct-2-Ene-2-Carboxylic Acid
Synonym Procef (6R,7R)-7-[[(2R)-2-Amino-2-(4-hydroxyphenyl)acetyl]amino]-8-oxo-3-(1-propen-1-yl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Prozef Cephprozyl Cefprozile BMY 28100 Cefprozil Cefzil
Chemical Name Translation头孢曲唑
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Sulfur & Selenium Compounds

产品应用

  • Semisynthetic oral cephalosporin consisting of approx. 90:10 Z/E isomeric mixture. Antibacterial.

相关文献及参考

  • Jones, R.N., et al.: Diagn. Microb. Infect. Dis., 9, 11 (1988),

安全信息

RTECSXI0339000 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 43,1238,1990

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   JJANAX Japanese Journal of Antibiotics.  (Japan Antibiotics Research Assoc.,
   2-20-8 Kamiosaki, Shinagawa-ku, Tokyo 141, Japan)  V.21-    1968-
   Volume(issue)/page/year: 43,1238,1990

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 7500 ug/kg/5D-I
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - chronic pulmonary edema
   Musculoskeletal - joints
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   125,325,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 100 mg/kg/5D-I
TOXIC EFFECTS :
   Musculoskeletal - joints
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
   JOPDAB Journal of Pediatrics.  (C.V. Mosby Co., 11830 Westline Industrial
   Dr., St. Louis, MO 63141) V.1-    1932-  Volume(issue)/page/year:
   125,3

系列性分类

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