GLYSOBUZOLE

CAS 3567-08-6 MFCD00865485

化学结构图

3567-08-6
SMILES: COc1ccc(S(=O)(=O)Nc2nnc(CC(C)C)s2)cc1

化学属性

Mol. FormulaC13H17N3O3S2
Mol. Weight327.45

别名和识别编码

Chemical NameBenzenesulfonamide,N-(5-isobutyl-1,3,4-thiadiazol-2-yl)-p-methoxy-
Wiswesser Line NotationT5NN DSJ CMSWR DO1& E1Y1&1
Synonym Glysobuzole 2-(p-Methoxybenzenesulfonamido)-5-isobutyl-1,3,4-thiadiazole 5-Isobutyl-2-p-methoxybenzenesulfonamido-1,3,4-thiadiazole Isobuzole 2-(p-Anisylsulfonamido)-5-isobutyl-1,3,4-thiadiazole Stabinol 1,3,4-Thiadiazole, 5-isobutyl-2-(p-methoxybenzenesulfonamido)- 8002 CB FWH 114
CAS Number3567-08-6
Beilstein Registry Number0295174
PubChem Substance ID234310
InChIInChI=1S/C13H17N3O3S2/c1-9(2)8-12-14-15-13(20-12)16-21(17,18)11-6-4-10(19-3)5-7-11/h4-7,9H,8H2,1-3H3,(H,15,16)
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 214 gm/kg/52W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,13,1966

RTECSDB2780000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 468 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,13,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Behavioral - ataxia
   Endocrine - hypoglycemia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   4,631,1962

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >1 gm/kg
TOXIC EFFECTS :
   Behavioral - tremor
   Behavioral - muscle weakness
   Gastrointestinal - nausea or vomiting
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,13,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 534 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   8,13,1966

系列性分类

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