2,2’-((Cyclohexane-1,1-Diylbis(4,1-Phenylene))Bis(Oxy))Bis(2-Methylbutanoic Acid) 2,2’-((环己烷-1,1-二基双(4,1-亚苯基))双(氧基))双(2-甲基丁酸)

CAS 30299-08-2 MFCD00865769

化学结构图

30299-08-2
SMILES: CC(CC)(OC1C=CC(=CC=1)C1(CCCCC1)C1C=CC(=CC=1)OC(C)(CC)C(O)=O)C(O)=O

化学属性

Mol. FormulaC28H36O6
Mol. Weight469
Melting Point142.0 to 146.0 deg-C

别名和识别编码

Chemical Name2,2’-((Cyclohexane-1,1-Diylbis(4,1-Phenylene))Bis(Oxy))Bis(2-Methylbutanoic Acid)
CAS Number30299-08-2
Synonym 1,1-Bis[4'-(1''-carboxy-1''-methylpropoxy)phenyl]cyclohexane 2,2'-[Cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-butanoic Acid 2,2'-(Cyclohexylidenebis(4,1-phenyleneoxy))bis(2-methylbutanoic acid) Clinofibrate 2,2'-(4,4'-Cyclohexylidenediphenoxy)-2,2'-dimethyldibutyric acid Lipoclin S 8527 2,2'-Cyclohexane-1,1-diylbis(p-phenyleneoxy)bis(2-methylbutyric acid)
Chemical Name Translation2,2’-((环己烷-1,1-二基双(4,1-亚苯基))双(氧基))双(2-甲基丁酸)
Beilstein Registry Number2230067
Reaxys-RN2230067
MDL NumberMFCD00865769
PubChem Substance ID253660897
Merck Number2357
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分类

  • Aromatics
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • An antilipemic, used as an anti-atherosclerosis agent

相关文献及参考

  • Cercos-Del-Pozo, R., et al.: J. Pharm. Pharmacol., 48, 240 (1996),

安全信息

RTECSES8900000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1930 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,219,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,219,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 230 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Skin and Appendages - hair
REFERENCE :
   YAKUD5 Gekkan Yakuji.  Pharmaceuticals Monthly.  (Yakugyo Jihosha, Inaoka
   Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-   1959-
   Volume(issue)/page/year: 23,1553,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >150 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,219,1982

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