2-(2-(4-chlorophenyl)benzo[d]oxazol-5-yl)propanoic acid 2-(2-(4-氯苯基)苯并[d]噁唑-5-基)丙酸

CAS 51234-28-7 MFCD00866099

化学结构图

51234-28-7
SMILES: CC(C(O)=O)C1=CC2N=C(OC=2C=C1)C1C=CC(Cl)=CC=1

化学属性

Mol. FormulaC16H12ClNO3
Mol. Weight301.74

别名和识别编码

Chemical Name2-(2-(4-chlorophenyl)benzo[d]oxazol-5-yl)propanoic acid
CAS Number51234-28-7
Synonym Uniprofen Opren Compound 90459 Coxigon 2-(4-Chlorophenyl)-alpha-methyl-5-benzoxazoleacetic acid Benoxaprofen Oraflex ########
Wiswesser Line NotationT56 BN DOJ CR DG& HY1&VQ
Beilstein Registry Number1085080
Chemical Name Translation2-(2-(4-氯苯基)苯并[d]噁唑-5-基)丙酸
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分类

  • Aromatics
  • Heterocycles
  • Isotope Labelled Compounds
  • Phamaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A non-steroidal anti-inflammatory ophthalmic agent.

相关文献及参考

  • Mathur, K., et al.: Bioorg. Med. Chem., 11, 1915 (2003),
  • Zhao, M., et al.: Bioorg. Med. Chem., 15, 2815 (2007),
  • Roy, K., et al.: Eur. J. Med. Chem., 44, 2913 (2009),

安全信息

RTECSDM4447000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 118 mg/kg
TOXIC EFFECTS :
   Behavioral - changes in motor activity (specific assay)
   Behavioral - ataxia
   Blood - aplastic anemia
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 9,4445,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 121 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - wom

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 800 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 18,53,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 780 mg/kg/13W-I
TOXIC EFFECTS :
   Endocrine - gynecomastia
REFERENCE :
   BMJOAE British Medical Journal.  (British Medical Assoc., BMA House,
   Tavistock Sq., London WC1H 9JR, UK)  V.1-    1857- Volume(issue)/page/year:
   284,1365,1982

TYPE OF TEST            : LD50

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Leukocyte
DOSE/DURATION           : 15 mg/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   48,3094,1988

系列性分类

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