Fludarabine Phosphate 磷酸氟达拉滨

CAS 75607-67-9 MFCD00866418

化学结构图

75607-67-9
SMILES: NC1=NC(F)=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O

化学属性

Mol. FormulaC10H13FN5O7P
Mol. Weight365
Melting Point203

别名和识别编码

Chemical NameFludarabine Phosphate
Synonym 9-(β-D-Arabinofuranosyl)-2-fluoroadenine 5'-Monophosphate,2-F-ara-AMP,2-Fluoroadenine 9-β-D-Arabinofuranoside 5'-Monophosphate Fludarabine phosphate NSC-312887 9-beta-Arabinofuranosyl-2-fluoroadenine-5'-phosphate 9-(-D-Arabinofuranosyl)-2-fluoroadenine 5'-Monophosphate,2-F-ara-AMP,2-Fluoroadenine 9--D-Arabinofuranoside 5'-Monophosphate
CAS Number75607-67-9
Chemical Name Translation磷酸氟达拉滨
MDL NumberMFCD00866418
Reaxys-RN8167686
Merck Number4126
PubChem Substance ID253660324
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安全信息

RTECSUO7440900 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 14245 mg/kg/5D
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - excitement
   Skin and Appendages - sweating
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 70,1449,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - child
DOSE/DURATION           : 18750 mg/kg/5D-I
TOXIC EFFECTS :
   Brain and Coverings - encephalitis
   Sense Organs and Special Senses (Eye) - visual field changes
REFERENCE :
   CTRRDO Cancer Treatment Reports.

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 11655 mg/kg/5D-I
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - visual field changes
   Sense Organs and Special Senses (Eye) - ptosis
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 70,1449,1986

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 23125 mg/kg/5D-I
TOXIC EFFECTS :
   Brain and Coverings - encephalitis
   Sense Organs and Special Senses (Eye) - visual field changes
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   CTRRDO Cancer Treatment Reports.  (Washington, DC)  V.60-71, 1976-87.  For
   publisher information,  see JNCIEQ.  Volume(issue)/page/year: 70,1225,1986

GHS Symbol
Signal word
Safety Statements
Risk Statements
Precautionary statements
  • P301+P312
  • P281 Use personal protective equipment as required. 使用所需的个人防护装备。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P263 Avoid contact during pregnancy/while nursing. 怀孕/哺乳期间避免接触。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
  • P405 Store locked up. 上锁保管。
  • P301+P312+P330
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
Hazard statements
  • H302 Harmful if swallowed 吞食有害

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Chemicals by Class 化学分类法
  4. Halogenated 卤化物 (氟氯溴碘)
  5. Fluoro 氟化物

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