Pregna-1,4-diene-3,20-dione,11-beta,17,21-trihydroxy-,21-(4-(p-(bis(2-chloroethyl)amino) phenyl)butyrate)

CAS 29069-24-7 MFCD00866487

化学结构图

29069-24-7
SMILES: C[C@]12C=CC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)COC(=O)CCCC1C=CC(=CC=1)N(CCCl)CCCl

化学属性

Mol. FormulaC35H45Cl2NO6
Mol. Weight646.71

别名和识别编码

Chemical NamePregna-1,4-diene-3,20-dione,11-beta,17,21-trihydroxy-,21-(4-(p-(bis(2-chloroethyl)amino) phenyl)butyrate)
Wiswesser Line NotationL E5 B666 OV AHTTT&J A1 CQ E1 FV1OV3R DN2G2G& FQ
Synonym Prednimustine NSC 134087 Chlorambucil prednisolone ester Chlorambucil ester of prednisolone Prednisolone 21-(4-(p-(bis(2-chloroethyl)amino)phenyl)butyrate) LEO 1031
Beilstein Registry Number2826967
CAS Number29069-24-7
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安全信息

RTECSTU4153000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 530 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   1,137,1976

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 13,873,1977

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   EJCAAH European Journal of Cancer.  (Oxford, UK)  V.1-17(6), 1965-1981. For
   publisher information, see EJCODS.  Volume(issue)/page/year: 13,873,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 16 mg/kg/4W
TOXIC EFFECTS :
   Behavioral - euphoria
   Blood - leukopenia
   Blood - thrombocytopenia
REFERENCE :
   JNMDBO Journal of Medicine (Westbury, NY).  (PJD Pub., Ltd., POB 966,
   Westbury, NY 11590) V.1-    1970-  Volume(issue)/page/year: 8,115,1977

系列性分类

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