Ethanesulfonamide,2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-N,N-dimethyl-

CAS 85977-49-7 MFCD00866540

化学结构图

85977-49-7
SMILES: CN(C)S(=O)(=O)CCNC(=O)N(CCCl)N=O

化学属性

Mol. FormulaC7H15ClN4O4S
Mol. Weight286.77

别名和识别编码

Chemical NameEthanesulfonamide,2-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-N,N-dimethyl-
Synonym LS-2667 2-((((2-Chloroethyl)nitrosoamino)carbonyl)amino)-N,N-dimethylethanesulfonamide Tauromustine 1-(2-Chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea Tauromustina TCNU
CAS Number85977-49-7
Chemical Name Translation
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信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

安全信息

RTECSKI7213500 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >7500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   11,585,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 39 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
   Liver - fatty liver degeneration
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 6,19,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 36 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - fatty liver degeneration
   Blood - thrombocytopenia
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1983- 
   Volume(issue)/page/year: 6,19,1988

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 42 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - other changes
   Liver - fatty liver degeneration
   Blood - thrombocytopenia
REFERENCE :
   INNDDK Investigational New Drugs. The Journal of New Anticancer Agents.
   Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA 02018)  V.1- 1

系列性分类

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