4-(4-(4-Bromophenyl)-4-Hydroxypiperidin-1-Yl)-1-(4-Fluorophenyl)Butan-1-One 4-(4-(4-溴苯基)-4-羟基哌啶-1-基)-1-(4-氟苯基)丁-1-酮
CAS 10457-90-6 MFCD00866670
化学结构图
SMILES: OC1(CCN(CCCC(=O)C2C=CC(F)=CC=2)CC1)C1C=CC(Br)=CC=1
化学属性
| Mol. Formula | C21H23BrFNO2 |
|---|---|
| Mol. Weight | 420 |
别名和识别编码
| Chemical Name | 4-(4-(4-Bromophenyl)-4-Hydroxypiperidin-1-Yl)-1-(4-Fluorophenyl)Butan-1-One |
|---|---|
| CAS Number | 10457-90-6 |
| Synonym | Bromperidol 4-(4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl)-1-(4-fluorophenyl)-1-butanone 4-(4-(p-Bromophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone 4-(4-(p-Bromophenyl)-4-hydroxypiperidinol)-4'-fluorobutyrophenone Bromoperidol 4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone 4-[4-(4-Bromophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone R 11333 4-(4-(4-Bromophenyl)-4-hydroxypiperidino)-4'-fluorobutyrophenone 1-Butanone, |
| MDL Number | MFCD00866670 |
| EC Number | 233-943-3 |
| Wiswesser Line Notation | T6NTJ A3VR DF& DQ DR DE |
| Beilstein Registry Number | 1552256 |
| Chemical Name Translation | 4-(4-(4-溴苯基)-4-羟基哌啶-1-基)-1-(4-氟苯基)丁-1-酮 |
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一流品牌服务
分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- Bromine analog of Haloperidol. Antipsychotic.
相关文献及参考
- Niemegeers, C.J.E., et al.: Life Sci., 24, 2201 (1979),
- Van Den Eeckhout, E., et al.: Eur. J. Drug Metab. Pharmacokinet., 5, 45 (1980),
- Vincent, S.H., et al.: J. Med. Chem., 23, 75 (1980),
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 10 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 323 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 16,1461,1985
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 359 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,45,1
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 114 mg/kg TOXIC EFFECTS : Sense Organs and Special Senses (Eye) - ptosis Behavioral - somnolence (general depressed activity) Behavioral - tremor REFERENCE : ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,45,1974
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 16500 ug/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Newborn - physical REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 9(Suppl 1),109,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 110 mg/kg SEX/DURATION : female 7-17 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight gain) REFERENCE : JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976- Volume(issue)/page/year: 9(Suppl 1),109,1984
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE : 1400 mg/kg SEX/DURATION : male 35 day(s) pre-mating TOXIC EFFECTS : Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands REFERENCE : IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(
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