Rifabutin 利福布汀

CAS 72559-06-9 MFCD00866816

化学结构图

72559-06-9
SMILES: C[C@]12OC3=C(C1=O)C1=C(C(=O)C(NC(=O)C(C)=CC=C[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@H](C=CO2)OC)=C2NC4(CCN(CC(C)C)CC4)N=C21)C(O)=C3C |c:17,63,t:19,39|

化学属性

Mol. FormulaC46H62N4O11
Mol. Weight847.02
Melting Point154.0 to 158.0 deg-C

别名和识别编码

Chemical NameRifabutin
CAS Number72559-06-9
Synonym 4-Deoxo-3,4-(2-spiro(N-isobutyl-4-piperidyl)-2,5-dihydro-1H-imidazo)-rifamycin S Rifabutine 1,4-Dihydro-1-deoxy-1',4-didehydro-5'-(2-methylpropyl)-1-oxorifamycin XIV LM 427 Rifabutin Antibiotic LM 427 1',4-Didehydro-1-deoxy-1,4-dihydro-5'-(2-methylpropyl)-1-oxorifamycin XIV
Chemical Name Translation利福布汀
Beilstein Registry Number3584778
Reaxys-RN3584778
MDL NumberMFCD00866816
Merck Number8213
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分类

  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Semisynthetic derivative of Rifamycin S that inhibits nucleic acid synthesis. An antibacterial (tuberculostatic).

相关文献及参考

  • O?Brien, R.J., et al.: Infect. Dis., 9, 519 (1987),
  • Anand, R., et al.: Antimicrob. AG. Chemother., 32 (684 (1988),
  • Skinner, M.H., et al.: Antimicrob. Agent Chemother., 33, 1237 (1989),

安全信息

RTECSVJ6700000 
TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ETPAEK Experimental and Toxicologic Pathology.  (Gustav Fischer Verlag Jena,
   Postfach 100537, D-07705 Jena, Germany)  V.44-    1992-
   Volume(issue)/page/year: 47,1,1995

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Primate - monkey
DOSE/DURATION           : >4 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ETPAEK Experimental and Toxicologic Pathology.  (Gustav Fischer Verlag Jena,
   Postfach 100537, D-07705 Jena, Germany)  V.44-    1992-
   Volume(issue)/page/year: 47,1,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 60 mg/kg/14D-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 348,685,1996

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspne

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE/DURATION           : 84 mg/kg/14D-I
TOXIC EFFECTS :
   Blood - agranulocytosis
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 348,685,1996

{hazard_

Storage condition <0°C

系列性分类

  1. Functional Group 官能团索引
  2. enol ether

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