4H-Pyrano(3,2-c)quinoline-2-carboxylic acid,5,6-dihydro-7,8-dimethyl-4,5-dioxo-, isopentyl ester

CAS 73080-51-0 MFCD00867034

化学结构图

73080-51-0
SMILES: CC(C)CCOC(=O)C1=CC(=O)C2=C(O1)C1C=CC(C)=C(C)C=1NC2=O

化学属性

Mol. FormulaC20H21NO5
Mol. Weight355.42

别名和识别编码

Chemical Name4H-Pyrano(3,2-c)quinoline-2-carboxylic acid,5,6-dihydro-7,8-dimethyl-4,5-dioxo-, isopentyl ester
CAS Number73080-51-0
Synonym Romet Isoamyl MY 5116 4H-Pyrano[3,2-c]quinoline-2-carboxylic acid, 5,6-dihydro-7,8-dimethyl-4,5-dioxo-, 3-methylbutyl Ester
Beilstein Registry Number4267921
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • Amines
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Antiallergic.

相关文献及参考

  • Phillipps, G., et al.: J. Med. Chem., 37, 3717 (1994),
  • Tronde, A., et al.: J. Pharm. Sci., 92, 1216 (2003),

安全信息

RTECSUQ1377000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2783 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - peritonitis
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 17,545,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 17,545,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Skin and Appendages - dermatitis, other (after systemic exposure)
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 17,545,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >5 gm/kg
TOXIC EFFECTS :
   Behavioral - food intake (animal)
   Nutritional and Gross Metabolic - weight loss or decrea

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 5200 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
   Reproductive - Fertility - abortion
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 17,51,1986

系列性分类

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