Morphinan-3,14-diol, 17-(cyclopropylmethyl)-

CAS 42281-59-4 MFCD00867730

化学结构图

42281-59-4
SMILES: O[C@@]12CCCC[C@]31CCN(CC1CC1)[C@@H]2CC1C=CC(O)=CC3=1

化学属性

Mol. FormulaC20H27NO2
Mol. Weight313.48

别名和识别编码

Chemical NameMorphinan-3,14-diol, 17-(cyclopropylmethyl)-
Wiswesser Line NotationT6 G666/FQ 2AF Q FX ONT&TTJ AQ IQ O1- AL3TJ
Synonym l-N-Cyclopropylmethyl-3,14-dihydroxymorphinan Oxilorphan (-)-3,14-Dihydroxy-N-(cyclobutylmethyl)morphinan (L)-BC-2605 Bristol laboratories BC 2605 (-)-17-Cyclopropylmethylmorphinan-3,4-diol
CAS Number42281-59-4
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安全信息

RTECSQC7800000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 193,23,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Human
DOSE/DURATION           : 26 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 315 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 193,23,1975

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human
DOSE/DURATION           : 14 ug/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Kidney, Ureter, Bladder - other changes
REFERENCE :
   JCPCBR Journal of Clinical Pharmacology.  (Hall Assoc., PO Box 482,
   Stamford, CT 06904) V.13-    1973-  Volume(issue)/page/year: 16,183,1976

系列性分类

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