TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 59 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory depression
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   GEIRDK Gendai Iryo.  Modern Medical Care.  (Towa Bldg., 2-7 Nishiki-cho,
   Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-    1969- Volume(issue)/page/year:
   14,188,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 32500 ug/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GEIRDK Gendai Iryo.  Modern Medical Care.  (Towa Bldg., 2-7 Nishiki-cho,
   Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-    1969- Volume(issue)/page/year:
   14,188,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 29500 ug/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   GEIRDK Gendai Iryo.  Modern Medical Care.  (Towa Bldg., 2-7 Nishiki-cho,
   Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-    1969- Volume(issue)/page/year:
   14,188,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 32500 ug/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   GEIRDK Gendai Iryo.  Modern Medical Care.  (Towa Bldg., 2-7 Nishiki-cho,

TYPE OF

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Human - woman
DOSE                    : 20 ug/kg
SEX/DURATION            : female 10 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 27,339,1983

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 438 ug/kg
SEX/DURATION            : female 1-7 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - extra-embryonic structures
   (e.g., placenta, umbilical cord)
REFERENCE :
   GEIRDK Gendai Iryo.  Modern Medical Care.  (Towa Bldg., 2-7 Nishiki-cho,
   Kanda, Chiyoda-ku, Tokyo 101, Japan)  V.1-    1969- Volume(issue)/page/year:
   14,809,1982

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 4 mg/kg
SEX/DURATION            : female 17 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - abortion
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravaginal
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 162 ug/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - F