N1,N3-Bis(2,3-Dihydroxypropyl)-5-(2-Hydroxy-N-(2-Hydroxyethyl)Acetamido)-2,4,6-Triiodoisophthalamide N1,N3-双(2,3-二羟丙基)-5-(2-羟基-N-(2-羟乙基)乙酰胺)-2,4,6-三碘异苯二甲酰胺

CAS 87771-40-2 MFCD00867959

化学结构图

87771-40-2
SMILES: OCCN(C1C(I)=C(C(I)=C(C=1I)C(=O)NCC(O)CO)C(=O)NCC(O)CO)C(=O)CO

化学属性

Mol. FormulaC18H24I3N3O9
Mol. Weight807.15

别名和识别编码

Chemical NameN1,N3-Bis(2,3-Dihydroxypropyl)-5-(2-Hydroxy-N-(2-Hydroxyethyl)Acetamido)-2,4,6-Triiodoisophthalamide
CAS Number87771-40-2
Synonym Optiray N,N'-bis(2,3-dihydroxypropyl)-5-[(hydroxyacetyl)(2-hydroxyethyl)amino]-2 Ioversol MP-328
Chemical Name TranslationN1,N3-双(2,3-二羟丙基)-5-(2-羟基-N-(2-羟乙基)乙酰胺)-2,4,6-三碘异苯二甲酰胺
Beilstein Registry Number7155654
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分类

  • Amines
  • Aromatics
  • Diagnostic
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Nonionic, low osmolality, radiographic contrast agent. Diagnostic aid (radiopaque medium).

相关文献及参考

  • Wilkins, R.A., et al.: Invest. Radiol., 24, 781 (1989),
  • Kaufman, A.J., et al.: Urol. Radiol., 12, 56 (1990),

安全信息

RTECSCZ2229000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 38372 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Liver - other changes
   Kidney, Ureter, Bladder - changes in tubules (including acute renal failure,
   acute tubular necrosis)
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 20,1127,1992

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Parenteral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 833 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 22,769,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 21200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 44,1275,1994

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intracerebral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1314 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 10

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 19 gm/kg
SEX/DURATION            : male 9 week(s) pre-mating
                          female 2 week(s) pre-mating  - 20 day(s) after
                          conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   INVRAV Investigative Radiology.  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1966-
   Volume(issue)/page/year: 24(Suppl 1),S16,1989

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 28800 mg/kg
SEX/DURATION            : female 17-21 day(s) after conception
                          lactating female 4 day(s) post-birth
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   INVRAV Investigative Radiology.  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1966-
   Volume(issue)/page/year: 24(Suppl 1),S16,1989

系列性分类

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