Cytidine diphosphate choline 胞嘧啶核苷二磷酸胆碱

CAS 987-78-0 MFCD00868097

化学结构图

987-78-0
SMILES: C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OC[C@H]1O[C@@H](n2ccc(N)nc2=O)[C@H](O)[C@@H]1O

化学属性

Mol. FormulaC14H26N4O11P2
Mol. Weight488
Appearance 本品钠盐为白色或类白色粉末，无臭；易吸湿。本品在水中易溶，在乙醇、丙酮、氯仿中不溶。有旋光性。

别名和识别编码

Chemical NameCytidine diphosphate choline
EC Number213-580-7
Synonym CDP-CHOLINE CDP-colina CYTIDINE 5'-DIPHOSPHOCHOLINE CYTIDINE DIPHOSPHATE CHOLINE Choline 5'-cytidine diphosphate Choline cytidine diphosphate Citicholin Citidin difosfato de colina Colite Cytidine 5'-(choline diphosphate) Cytidine 5'-(trihydrogen diphosphate), P'-[2-(trimethylammonio)ethyl] ester Cytidine 5'-diphosphate choline Cytidine 5'-diphosphate choline; Cytidine 5'-diphosphocholine; Cytidine choline diphosphate; Cytidine diphosphate choline; Cytidine diphosphate choline ester; Cytidine diphosphocholine; Cytidine diphosphorylcholine; Cytidine 5'-(trihydrogen diphosphate) P'-[2-(trime Cytidine 5'-diphosphocholine Cytidine choline diphosphate Cytidine diphosphate cholin ester Cytidine diphosphate choline Cytidine diphosphocholine {} {ha
CAS Number987-78-0
MDL NumberMFCD00037486
Chemical Name Translation胞嘧啶核苷二磷酸胆碱
Wiswesser Line NotationT6NVNJ DZ A- BT5OTJ CQ DQ E1OPQO&OPWO2K1&1&1 &39/36
Beilstein Registry Number4170138
LabNetwork Molecule IDLN01344847
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相关文献及参考

  • [2]. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7.
  • [1]. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.
  • [1]. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.
  • [2]. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7.

安全信息

RTECSGA4027000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5344 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 4472 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 20,109,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 8218 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - antipsychotic
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Ke

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 6485 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - convulsions or effect on seizure threshold
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 20,109,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSUR

GHS Symbol
Precautionary statements
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。

其他信息

  • 用途二:该品是卵磷酯生物合成前体，能促使卵磷脂生物合成。该品可促进大脑功能的恢复和苏醒。适用于脑外伤、中风后遗症等的意识障碍，也用于中枢神经系统急性损伤所致意识障碍。
  • 方法一:可从肝或酵母提取，也可通过化学合成。合成法以胞嘧啶-5'-二磷酸与乙烯亚胺反应生成胞嘧啶-5'-二磷酸氨基乙酯，然后用碘甲烷甲基化即得。也可将胞嘧啶-5'-磷酸酰胺与磷酸胆碱酯直接缩合而得。
  • 用途一:用于急性颅脑外伤及脑手术后的意识障碍。脑血栓、多发性脑栓塞、震颤麻痹、中风后遗症、脑动脉硬化所致脑供血不足、催眠药和一氧化碳中毒及各种器质性脑病。
  • MOL 文件:987-78-0.mol
  • 上游原料:碘甲烷 --> 氮丙啶 --> 酵母萃取物 --> 胞嘧啶 --> 磷酸胆碱

系列性分类

  1. Medical Research Areas
  2. Metabolism
  3. Endogenous Metabolite  (内源性代谢物)

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