5H-2,3-Benzodiazepine,1-(4-aminophenyl)-7,8-dimethoxy-4-methyl-

CAS 102771-12-0 MFCD00868171

化学结构图

102771-12-0
SMILES: CC1CC2=CC(OC)=C(C=C2C(=NN=1)C1=CC=C(N)C=C1)OC

化学属性

Mol. FormulaC18H19N3O2
Mol. Weight309.40

别名和识别编码

Chemical Name5H-2,3-Benzodiazepine,1-(4-aminophenyl)-7,8-dimethoxy-4-methyl-
Synonym Nerisopam GYKI 52322 1-(4-Aminophenyl)-7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepine Benzenamine, 4-(7,8-dimethoxy-4-methyl-5H-2,3-benzodiazepin-1-yl)- 1-(4-Aminophenyl)-4-methyl-7,8-dimethoxy-5H-2,3-benzodiazepine
CAS Number102771-12-0
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安全信息

RTECSDE8746050 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 182 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 39,894,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 275 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 39,894,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 128 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 39,894,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 108 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Lungs, Thorax, or Respiration - cyanosis
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   ARZNAD

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