Mefeclorazine

CAS 1243-33-0 MFCD00868973

化学结构图

1243-33-0
SMILES: COc1ccc(CCN2CCN(c3ccccc3Cl)CC2)cc1OC

化学属性

Mol. FormulaC20H25ClN2O2
Mol. Weight360.92

别名和识别编码

Chemical NamePiperazine,1-(o-chlorophenyl)-4-(3,4-dimethoxyphenethyl)-
Wiswesser Line NotationT6N DNTJ A2R CO1 DO1& DR CG
Synonym 1-o-Chlorophenyl-4-(3,4-dimethoxyphenethyl)piperazine SD 218-06 N-(Dimethoxy-3,4-phenethyl),-N'-(chloro-2-phenyl) piperazine Mepheclorazin 1-(2-Chlorphenyl)-4-(3,4-dimethoxyphenethyl)piperazine Mefeclorazine
CAS Number1243-33-0
Beilstein Registry Number0627902
PubChem Substance ID3064105
InChIInChI=1S/C20H25ClN2O2/c1-24-19-8-7-16(15-20(19)25-2)9-10-22-11-13-23(14-12-22)18-6-4-3-5-17(18)21/h3-8,15H,9-14H2,1-2H3
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安全信息

RTECSTL2803000
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Autonomic Nervous System - central sympatholytic
   Vascular - BP elevation not characterized in autonomic section
   Lungs, Thorax, or Respiration - bronchiolar dilation
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 8,104,1965

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : >2 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   PSCBAY Psychopharmacology Service Center, Bulletin.  (Bethesda, MD)  V.1-3,
   1961-65.  For publisher information, see PSYBB9.  Volume(issue)/page/year:
   2,17,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 55 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 133,29,1961

系列性分类


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