N-Hydroxy-4-acetylaminobiphenyl

CAS 4463-22-3 MFCD00869966

化学结构图

4463-22-3
SMILES: CC(=O)N(O)c1ccc(-c2ccccc2)cc1

化学属性

Mol. FormulaC14H13NO2
Mol. Weight227.28

别名和识别编码

Chemical NameN-Hydroxy-4-acetylaminobiphenyl
Wiswesser Line Notation1VNQR DR
Synonym N-Hydroxy-N-4-biphenylacetamide N-Hydroxy-4-acetylaminobiphenyl N-Hydroxy-4-acetamidobiphenyl N-4-(N-Hydroxyacetamido)biphenyl N-Acetyl-4-biphenylhydroxylamine N-(1,1'-Biphenyl)-4-yl-N-hydroxyacetamide N-4-Biphenylylacetohydroxamic acid N-Hydroxy-4-acetamidodiphenyl 4-Biphenylacethydroxamic acid N-Hydroxy-aabp Acetamide, N-(1,1'-biphenyl)-4-yl-N-hydroxy- N-Acetyl-N-hydroxy-4-aminobiphenyl
Beilstein Registry Number2807692
CAS Number4463-22-3
InChIKeyUNHSJQXRZCIATF-UHFFFAOYSA-N
PubChem Substance ID20527
InChIInChI=1S/C14H13NO2/c1-11(16)15(17)14-9-7-13(8-10-14)12-5-3-2-4-6-12/h2-10,17H,1H3
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安全信息

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 91 mg/kg
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,2450,1981

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1430 mg/kg/21W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   21,1465,1961

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2400 mg/kg/16W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Skin and Appendages - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   21,1465,1961

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Implant
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 80 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmill

RTECSAK8225000 
TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Cells - not otherwise specified
DOSE/DURATION           : 10 umol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   42,3974,1982

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 290 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 88,397,1981

TYPE OF TEST            : DNA damage
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 25 mg/kg
REFERENCE :
   COINAV Colloques Internationaux du Centre National de la Recherche
   Scientifique.  (Kluwer Academic Pub., POB 358, Accord Stn., Hingham, MA
   02018)  V.1-    1946-  Volume(issue)/page/year: 256,115,1977

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 10 umol/L/5H
REFERENCE :
   IJCNAW International Journal of Cancer.  (International Union Against
   Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland)  V.1-    1966-
   Volume(issue)/page/year: 16,284,1975

TYPE OF TEST            : Morphological transformation
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 27276 pg/kg
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 11,333,1990

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Mammal - dog Cells - not otherwise specified
DOSE/DURATION           : 1 umol/L
REFERENCE :

系列性分类

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