L-Glutamine,N-(2-((2-((8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-methoxy-5-methyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)amino )ethyl)dithio) ethyl)-,(1aS-(1a-alpha,8-beta,8a-alpha,8b-alpha))-

CAS 118359-59-4 MFCD00870166

化学结构图

118359-59-4
SMILES: CC1C(=O)C2=C([C@@H](COC(N)=O)[C@@]3(OC)[C@H]4N[C@H]4CN32)C(=O)C=1NCCSSCCNC(=O)CC[C@H](N)C(O)=O

化学属性

Mol. FormulaC24H34N6O8S2
Mol. Weight598.76

别名和识别编码

Chemical NameL-Glutamine,N-(2-((2-((8-(((aminocarbonyl)oxy)methyl)-1,1a,2,4,7,8,8a,8b-octahydro-8a-methoxy-5-methyl-4,7-dioxoazirino(2',3':3,4)pyrrolo(1,2-a)indol-6-yl)amino )ethyl)dithio) ethyl)-,(1aS-(1a-alpha,8-beta,8a-alpha,8b-alpha))-
Synonym 7-N-((2-((2-(R-L-Glutamylamino)ethyl)dithio)ethyl))mitomycin C KW 2149 7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin C KT6149
CAS Number118359-59-4
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安全信息

RTECSMA2275265 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 19600 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DRFUD4 Drugs of the Future.  (J.R. Prous, S.A., Apartado de Correos 540,
   08080 Barcelona, Spain) V.1-    1975/76-  Volume(issue)/page/year:
   14,127,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 22500 ug/kg
TOXIC EFFECTS :
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 37,1128,1989

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 7500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GTKRDX Gan to Kagaku Ryoho.  Cancer and Chemotherapy.  (1-8-9 Yaesu,
   Chuo-ku, Tokyo 103, Japan) V.1-    1974-  Volume(issue)/page/year:
   16,2189,1989

系列性分类

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