Loperamide N-Oxide

CAS 106900-12-3 MFCD00870596

化学结构图

106900-12-3
SMILES: CN(C)C(=O)C(CC[N@@+]1([O-])CC[C@@](O)(CC1)C1C=CC(Cl)=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1 |&1:8,12|

化学属性

Mol. FormulaC29H33ClN2O3
Mol. Weight493

别名和识别编码

Chemical Name1-Piperidinebutanamide,4-(4-chlorophenyl)-4-hydroxy-N,N-dimethyl-alpha,alpha-diphenyl-, 1-oxide, (E)-
CAS Number106900-12-3
Synonym trans- Loperamide N-oxide R 58425 trans-N-Oxide of loperamide
Chemical Name Translation
MDL Number
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分类

  • Drug Analogues
  • Heterocycles
  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals,

产品应用

  • Loperamide oxide (LOPOX) is a prodrug of Loperamide (LOP). It is concluded that Loperamide oxide administered intraluminally is reduced to Loperamide and has the same antisecretory potency as Loperami

相关文献及参考

  • Lavrijsen, K., et al.: Drug Metab. Dispos., 23, 354

安全信息

RTECSTM4960200 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 28300 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 8,279,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 172 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   DDREDK Drug Development Research.  (Alan R. Liss, Inc., 41 E. 11th St., New
   York, NY 10003) V.1-    1981-  Volume(issue)/page/year: 8,279,1986

系列性分类

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