Febuxostat 非布索坦

CAS 144060-53-7 MFCD00871598

化学结构图

144060-53-7
SMILES: Cc1nc(-c2ccc(OCC(C)C)c(C#N)c2)sc1C(=O)O

化学属性

Mol. FormulaC16H16N2O3S
Mol. Weight316
Melting Point207.0 to 211.0 deg-C

别名和识别编码

Chemical NameFebuxostat
CAS Number144060-53-7
Synonym 2-(3-Cyano-4-isobutyloxyphenyl)-4-methyl-5-thiazolecarboxylic Acid 2-(3-cyano-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylic acid 2-[3-Cyano-4-(2-methylpropoxy)phenyl]-4-methyl-5-thiazolecarboxylic Acid 6720, TEI TEI 6720 TEI-6720 TEI6720 TMX 67 febuxostat uloric
Chemical Name Translation非布索坦
MDL NumberMFCD00871598
Reaxys-RN8005333
Merck Number3948
PubChem Substance ID172089002
LabNetwork Molecule IDLN01299063
InChIInChI=1S/C16H16N2O3S/c1-9(2)8-21-13-5-4-11(6-12(13)7-17)15-18-10(3)14(22-15)16(19)20/h4-6,9H,8H2,1-3H3,(H,19,20)
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分类

  • Heterocycles
  • Inhibitors
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.

相关文献及参考

  • Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993),
  • Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003),
  • Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005),

安全信息

Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H302+H312+H332
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
RTECSXJ3675310
GHS Symbol
Signal word
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312
  • P301+P312+P330
  • P302+P352+P312+P362+P364
  • P304+P340+P312
  • P305+P351+P338+P337+P313
  • P330 Rinse mouth. 漱口
  • P501 Dispose of contents/container to..… 处理内容物/容器.....

系列性分类

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