Spiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-one,6'-hydroxy-3'-(hydroxymethyl)-2',4',6'- trimethyl-,(R)-

CAS 158440-71-2 MFCD00931906

化学结构图

158440-71-2
SMILES: C[C@]1(O)C(=O)C2=CC(C)=C(CO)C2=C(C)C21CC2

化学属性

Mol. FormulaC15H18O3
Mol. Weight246.33

别名和识别编码

Chemical NameSpiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-one,6'-hydroxy-3'-(hydroxymethyl)-2',4',6'- trimethyl-,(R)-
CAS Number158440-71-2
Synonym NSC 683863 (-)-(Hydroxymethyl)acylfulvene Acylfulvene, 6-(hydroxymethyl)- 6-(Hydroxymethyl)acylfulvene (6'R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one HMAF MGI 114 (-)-Irofulven
Chemical Name Translation
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
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分类

  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • Semi-synrhetic antitumor agent derived from Illudin S. Inhibits DNA synthesis and induces apoptosis in tumor cells. Antineoplastic.

相关文献及参考

  • Woynarowski, J.M., et al.: Biochem. Pharmacol., 54, 1181 (1997),
  • Alexandre, J., et al.: Clin. Cancer Res., 10, 3377 (2004),
  • Senzer, N., et al.: Am. J. Clin. Oncol., 28, 36 (2005),

安全信息

RTECSWH0204487 
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 2 mg/kg
TOXIC EFFECTS :
   Blood - thrombocytopenia
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in other cell count (unspecified)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year: 36(1,
   Pt 2),180,1997

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >6610 ug/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Blood - changes in bone marrow (not otherwise specified)
   Blood - changes in other cell count (unspecified)
REFERENCE :
   FAATDF Fundamental and Applied Toxicology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1981-  Volume(issue)/page/year: 36(1,
   Pt 2),180,1997

系列性分类

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