1-Propanone,1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-, hydrochloride (1:1) 1-(4-乙基苯基)-2-甲基-3-(1-哌啶基)-1-丙酮盐酸盐

CAS 56839-43-1 MFCD00941459

化学结构图

56839-43-1
SMILES: Cl.CCC1=CC=C(C=C1)C(=O)C(C)CN1CCCCC1

化学属性

Mol. FormulaC17H26ClNO
Mol. Weight296

别名和识别编码

Chemical Name1-Propanone,1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-, hydrochloride (1:1)
CAS Number56839-43-1
Synonym 4'-Ethyl-2-methyl-3-piperidinopropiophenone hydrochloride Mional 1-Propanone, 1-(4-ethylphenyl)-2-methyl-3-(1-piperidinyl)-, hydrochloride 4'-Ethyl-2-methyl-3-piperidinopropiophenone Hydrochloride E 0646 1-(4-Ethylphenyl)-2-methyl-3-(1-piperidinyl)-1-propanone Hydrochloride EMPP Eperisone hydrochloride Myonal E-646
Wiswesser Line NotationT6NTJ A1Y1&VR D2 &GH
Chemical Name Translation1-(4-乙基苯基)-2-甲基-3-(1-哌啶基)-1-丙酮盐酸盐
MDL Number
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分类

  • Aromatics
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).

相关文献及参考

  • Catterall, W., et al.: J. Biol. Chem., 256, 892 (1981),

安全信息

RTECSUH1755000 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1002 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - lacrimation
   Autonomic Nervous System - smooth muscle relaxant (mechanism undefined,
   spasmolytic)
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   YACHDS Yakuri to Chiryo.  Pharmacology and Therapeutics.  (Raifu Saiensu
   Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan)  V.1-    1972-
   Volume(issue)/page/year: 19,1743,1991

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 43 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 21,939,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 256 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 21,939,1981

系列性分类

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