(S)-1-[2-[(3-Hydroxyadamant-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile (2S)-1-((3-羟基三环[3.3.1.1[3,7]]癸烷-1-基)氨基)乙酰基)吡咯烷-2-腈

CAS 274901-16-5 MFCD09952339

化学结构图

274901-16-5
SMILES: N[C@@H](CC(=O)N1CC2=NN=C(N2CC1)C(F)(F)F)CC1C=C(F)C(F)=CC=1F.OP(O)(O)=O

化学属性

Mol. FormulaC17H25N3O2
Mol. Weight303
Density1.27
Boiling Point531.3

别名和识别编码

Chemical Name(S)-1-[2-[(3-Hydroxyadamant-1-yl)amino]acetyl]pyrrolidine-2-carbonitrile
CAS Number274901-16-5
Synonym (2S)-
Chemical Name Translation(2S)-1-((3-羟基三环[3.3.1.1[3,7]]癸烷-1-基)氨基)乙酰基)吡咯烷-2-腈
MDL Number
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分类

  • Amines
  • Chiral Reagents
  • Heterocycles
  • Pharmaceuticals
  • Intermediates & Fine Chemicals

产品应用

  • It is a new oral anti-hyperglycemic agent of a new dipeptidyl peptidase-IV (DPP-IV) inhibitor class of drugs. Antidiabetic.

相关文献及参考

  • [2]. Wu YJ, et al. Dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits pancreatic beta cell apoptosis in associationwith its effects suppressing endoplasmic reticulum stress in db/db mice. Metabolism. 2015 Feb;64(2):226-35.
  • Ahren, B., et al.: Diabetes Care, 27, 2874 (2004),
  • Ahren, B., et al.: J. Clin. Endocrinol. Metab., 89, 2078 (2004),
  • Barlocco, D., et al.: Curr. Opin. Invest. Drugs, 5, 1094 (2004),
  • [1]. Villhauer EB, et al. 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem. 2003 Jun 19;46(13):2774-89.
  • [1]. Villhauer EB, et al. 1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties. J Med Chem. 2003 Jun 19;46(13):2774-89.
  • [2]. Wu YJ, et al. Dipeptidyl peptidase-4 in

安全信息

GHS Symbol
UN Number
Hazard Codes
Signal word
Safety Statements
Risk Statements
Precautionary statements
Packing GroupIII

系列性分类


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