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分类

• {uni_hamburg} no charge; alcohol; 1fragment
• {SNA} Alcohols, Building Blocks, C2 to C6, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds

产品应用

• 用于有机合成、药物中间体。

相关文献及参考

• Reaction with POCl3 to give the phosphorodichloridate, followed by reaction with 3-Hydroxypropionitrile, L12570, gives 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a valuable reagent, usually used without purification, for the phosphorylation of nucleosides: Synthesis, 831 (1980).
• Reaction with POCl3 to give the phosphorodichloridate, followed by reaction with 3-Hydroxypropionitrile, L12570, gives 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a valuab
• Short: III/38B
• Short: EINECS
• Carboxyl groups can be protected as their trichloroethyl esters e.g. by tosic acid-catalyzed esterification: Synthesis, 24 (1979), or DCC-DMAP: J. Am. Chem. Soc., 111, 669 (1989). For esterification of amino acids, using the active ester with 2-Hydroxypyridine, A14522, see: Synthesis, 24 (1979). Cleavage occurs with Zn in AcOH or an aqueous THF buffer under mild conditions: J. Am. Chem. Soc., 88, 852 (1966); Synthesis, 457 (1976); or with NaBH4 in DMF, catalyzed by Se: Synthesis, 693 (1989). See also Appendix 6.
• Merck:14,9638 Beilstein:1,338
• Similarly, carbonyl compounds can be protected as their trichloroethyl acetals, stable to base, but readily cleaved under neutral aprotic conditions by Zn in ethyl acetate or THF: J. Org. Chem., 38, 554 (1973).
• Merck:14,9638

安全信息

GHS Symbol

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CRAAA7 Current Researches in Anesthesia and Analgesia.  (Cleveland, OH)
   V.1-35, 1922-56.  For publisher information, see AACRAT.
   Volume(issue)/page/year: 17,258,1938

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Rectal
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CRAAA7 Current Researches in Anesthesia and Analgesia.  (Cleveland, OH)
   V.1-35, 1922-56.  For publisher information, see AACRAT.
   Volume(issue)/page/year: 17,258,1938

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - sleep
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 63,453,1938

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 500 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - respiratory depression
   Lungs, Thorax, or Respiration - other changes
REFERENCE :
   CRAAA7 Current Researches in Anesthesia and Analgesia.  (Cleveland, OH)
   V.1-35, 1922-56.  For publisher information, see

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 7750 ug/plate
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   30,9,1980

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 178 gm/L
REFERENCE :
   TOERD9 Toxicological European Research.  (S.P.E., 10, Ave. de Messine, 75008
   Paris, France) V.1-    1978-  Volume(issue)/page/year: 3,63,1981

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Mold - Aspergillus nidulans
DOSE/DURATION           : 10240 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 155,105,1985

其他信息

• 无色液体。能与醇、醚混溶，溶于水，水溶液pH为5-6。易吸湿，有醚的气味。
• 蒸气压:1 mm Hg ( 20 °C)
• 毒性LD50(mg/kg):小鼠静脉注射LD50为201。
• 用途一:用作医药中间体
• 上游原料:三氯乙醛
• 蒸气密度:5.16 (vs air)
• 图谱信息:2,2,2-三氯乙醇(115-20-8)核磁图( 13 CNMR) 2,2,2-三氯乙醇(115-20-8)红外图谱(IR1) 2,2,2-三氯乙醇(115-20-8)质谱(MS) 2,2,2-三氯乙醇(115-20-8)核磁图( 1 HNMR) 2,2,2-三氯乙醇(115-20-8)Raman光谱
• 用途三:2,2,2-三氯乙醇（115-20-8）是苯甘头孢菌素的原料，羧（酸）基的保护基团。
• 方法一:由三氯乙醛还原而得。
• Acros Organics:2,2,2-三氯乙醇 2,2,2-Trichloroethanol, 99%(115-20-8)
• 外观形状:无色透明液体，菱形片状结晶（低温），或吸湿性液体。有醚样嗅味。
• Alfa Aesar:2,2,2-三氯乙醇,98% 2,2,2-Trichloroethanol, 99%(115-20-8)
• 用途二:用于有机合成、药物中间体。
• F:3-21
• 敏感性:Hygroscopic
• TCI Shanghai:2,2,2-三氯乙醇 2,2,2-Trichloroethanol,>;98.0%(GC)(115-20-8)
• 下游产品:氯甲酸-2,2,2-三氯乙酯 --> 对乙基苯甲酸 --> 3-甲基-8-氧代-7-(2-苯乙酰氨基)-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-乙羧酸-2,2,2-三氯乙酯
• MOL 文件:115-20-8.mol
• Sigma Aldrich:115-20-8(sigmaaldrich)
• 2,2,2-三氯乙醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 xw010350 2,2,2-三氯乙醇 100ml 400元 2011/04/16 T0622 2,2,2-三氯乙醇 2,2,2-Trichloroethanol 25G 196元 2011/04/16 T0622 2,2,2-三氯乙醇 2,2,2-Trichloroethanol 500G 1130元
• 海关编码:29055910
• MSDS 信息:Trichloroethanol(115-20-8).msds