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• 试剂商城
• 直接询价

分类

• {SNA} Chemical Reagents, Chemical Synthesis, Development Quantities for Research, Protecting and Derivatizing Reagents, Protection and Derivatization, Silicon-Based, Synthetic Reagents
• {SNA} Analytical/Chromatography,
• {uni_hamburg} no charge; 1fragment
• {SNA} Chemical Synthesis, Protecting and Derivatizing Reagents, Protection and Derivatization, Silicon-Based, Synthetic Reagents
• {SNA} Chemical Synthes
• {SA} Analytical Reagents, Analytical/Chromatography, Chemical Synthesis, Derivatization Reagents, Derivatization Reagents GC, Protecting and Derivatizing Reagents, Protection and Derivatization, Reagents for Silylation, Silicon-Based, Silylation Reagents, Synthetic Reagents

产品应用

• 用作硅酮油制造的中间体、憎水剂、分析用试剂、 聚硅酮液中间体、甲基硅油封头剂、抗水剂。

相关文献及参考

• Carbonyl compounds can be converted to their silyl enol ethers, e.g. with triethylamine in DMF: Org. Synth. Coll., 6, 327 (1988); 7, 424 (1990); 8, 460 (1993); or using catalysis with NaI: Org. Synth. Coll., 9, 573 (1998).
• The conversion of alcohols to alkyl chlorides requires catalysis, e.g. SeO2: J. Org. Chem., 53, 3634 (1988), or by DMSO: J. Org. Chem., 60, 2638 (1995). The same system is also effective in opening epoxides.
• For further details and reviews, see Appendix 4.
• For cleavage of ethers, see Sodium iodide, A15480.
• Conjugated enones give trimethylsilyloxydienes. For examples, see: Org. Synth. Coll., 6, 445 (1988); 7, 282 (1990). TMS chloride, LiBr and trimethylamine in THF is a convenient system for silylation of enones: Acta Chem. Scand., 43, 188 (1989). The same combination converts ɑ- and ß-diketones to their bis silyl enol ethers: Acta Chem. Scand., 43, 304 (1989). See also Trimethyl­silyl­ trifluoromethanesulfonate, A12535.
• Short: II/25C
• Merck: 14,10311
• Short: II/14a
• Silylation at carbon atoms is usually carried out using organometallic reagents, e.g. vinylmagnesium bromide: Org. Synth. Coll., 6, 1033 (1988). In aromatic rings, silyl groups can be introduced by directed metallation, followed by silylation; see e.g.: J. Org. Chem., 49, 4657 (1989). The silyl substituents can readily be replaced by electrophiles, allowing "abnormal" patterns of substitution. See 1,3-Dimethoxybenzene, A13380.
• Merck: 14,10311 Beilstein:4(3)1857
• Short: II/2
• For facile O-silylation of tertiary alcohols in the presence of Mg metal, see: Synlett, 1025 (2000).

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 mg/kg/I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   54,495,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1780 uL/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 12,574,1993

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/m3
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   USKHAB Uspekhi Khimii. Progress in Chemistry.  For English translation, see
   RCRVAB. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1932-
   Volume(issue)/page/year: 38,2173,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5660 uL/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - dyspnea
   Gastrointestinal - other changes
REFERENCE :
   ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology,
   Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128)  V.1-
   1990-  Volume(issue)/page/year: 12,574,1993

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 750 mg/kg
TOXIC EFFECTS :
   Immunological Including Allergic - decreased immune response
REFERENCE :

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 8(Suppl
   7),1,1986

其他信息

• TCI Shanghai:三甲基氯硅烷 Chlorotrimethylsilane,>;98.0%(GC)(75-77-4)
• 海关编码:29310095
• 方法一:氯甲烷与
• 急性毒性:吸入- 小鼠 LCL0: 100 毫克/ 立方米; 腹腔- 小鼠 LDL0: 750 毫克/ 公斤
• Hazard Note:Highly Flammable/Corrosive/Moisture Sensitive
• Acros Organics:Chlorotrimethylsilane, AcroSeal?, 98%(75-77-4)
• 蒸气密度:3.7 (vs air)
• {Ch
• 灭火剂:干粉、干砂、二氧化碳、泡沫
• 上游原料:乙酰氯 --> 氯化亚铜 --> 氯甲烷 --> 硅 --> 氯甲基硅烷 --> 四甲基硅烷
• Sigma Aldrich:75-77-4(sigmaaldrich)
• Alfa Aesar:三甲基氯硅烷,98+% Chlorotrimethylsilane, 98+%(75-77-4)
• 毒性分级:中毒
• 可燃性危险特性:遇明火、高
• 三甲基氯硅烷价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80135626 三甲基氯硅烷;氯化三甲矽 100ml 30.7元 2011/08/23 40060560 三甲基氯硅烷;氯化三甲矽 100ml 37.7元 2011/04/16 C0306 三甲基氯硅烷 Chlorotrimethylsilane 25ML 198元
• 类别:易燃液体
• MSDS 信息:三甲基氯硅烷(75-77-4).msds
• MOL 文件:75-77-4.mol
• F:10-21
• TSCA:Yes
• 防护措施:参见“二甲基二氯硅烷”。
• 用途一:本品可用于生产多种有机硅化合物，是生产六甲基二硅氮（胺）烷和六甲基二硅氧烷
• 常规方法:参见“二甲基二氯硅烷”。
• 图谱信息:三甲基氯硅烷(75-77-4)质谱(MS) 三甲基氯硅烷(75-77-4)红外图谱(IR1) 三甲基氯硅烷(75-77-4)核磁图( 1 HNMR) 三甲基氯硅烷(75-77-4)核磁图( 13 CNMR)
• 蒸气压:100 mm Hg ( 25 °C)
• 下游产品:N-乙基双氧哌嗪酰氨苯乙酸 --> 5-氟-2-吡啶羧酸 --> (三氟甲基)三甲基硅烷 --> 六甲基二硅氮烷 --> 2-噻吩乙胺 --> 3-羧甲基绕丹宁 --> 三氧化硫吡啶 --> (6R,7R)-3-[[(1-甲基-1H-四唑-5-基)硫]甲基]-7-[(R)-2-(4-乙基-2,3-二氧代-1-哌嗪甲酰氨基)-2-对羟基苯基-乙酰氨基]-8-氧代-5-硫杂-1-氮杂双环[4.2.0]辛-2-烯-2-甲酸 --> 反-1-甲氧基-3-(三甲基硅氧基)-1,3-丁二烯 --> 三甲基乙炔基硅 --> 氧哌嗪酸 --> 六甲基二硅氧烷 --> 3-氟-5-溴-2-吡啶酮 --> 阿尼西坦 --> 三(三甲基硅基)硅烷 --> 噻唑-4-甲醛 --> 6-氰基烟酸 --> 罗他霉素 --> 2-(三甲基硅)苯基三氟甲烷磺酸盐 --> 7-氨基头孢烷酸 --> 二(三甲基甲硅烷基)乙炔 --> 叠氮基三甲基硅烷 --> 4-碘代苯乙酮 --> 三甲基乙氧基硅烷 --> 双(三甲基硅基)过氧化物 --> 2,4-二甲基喹啉-3-羧酸乙酯 --> 替加氟 -->
• 用途三:该品主要用作生产有机硅聚合物及其他产品的中间体，还用作高分子化合物封头剂、干燥剂、脱水剂、高温粘合剂及树脂的原料。在医药生产中用于头孢菌素Ⅰ、头孢菌素V的合成。
• 用途四:用作硅酮油制造的中间体、憎水剂、分析用试剂、 聚硅酮液中间体、甲基硅油封头剂、抗水剂。