Dimethylcarbamoyl chloride 二甲胺基甲酰氯

CAS 79-44-7 MFCD00000635

化学结构图

79-44-7
SMILES: CN(C)C(=O)Cl

化学属性

Mol. FormulaC3 H6 Cl N O
Mol. Weight107.54
Refractive index1.4520 to 1.4540
Boiling Point
Density1.171
Melting PointNo Data Available
Flash Point68.33°C
TSCAYes
Solubility分解
Stability对湿度敏感
pH:A

别名和识别编码

Chemical NameDimethylcarbamoyl chloride
Synonym Carbamoyl chloride, dimethyl- Carbamyl chloride, N,N-dimethyl- DIMETHYLAMINOFORMYL CHLORIDE DIMETHYLCARBAMOYL CHLORIDE DMCC Dimethyl carbamoyl chloride Dimethylcarbamic acid chloride Dimethylcarbamoyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL NumberMFCD00000635
CAS Number79-44-7
PubChem Substance ID87567335
EC Number201-208-6
Beilstein Registry Number878197
Chemical Name Translation二甲胺基甲酰氯
Reaxys-RN878197
Wiswesser Line NotationGVN1&1
LabNetwork Molecule IDLN00222428
InChIInChI=1S/C3H6ClNO/c1-5(2)3(4)6/h1-2H3
Canonical SMILESO=C(Cl)N(C)C
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分类

  • {Chemicalbook} 农药中间体: 杀虫剂中间体: 氨基甲酸酯类杀虫剂
  • {uni_hamburg} no charge; carbonyl chloride; 1fragment
  • {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks

产品应用

  • 用作医药、农药、染料、塑料、合成材料及其他精细有机化工产品的合成，例如用于生产溴化新期的明、甲基硫酸新斯的明、吡啶斯的明，氨基甲酸酯类杀虫剂等。

相关文献及参考

  • Short: II/25C
  • Short: III/20a
  • Beilstein:4,73

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H331 Toxic if inhaled 吸入中毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H350 May cause cancer 可能致癌
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P201 Obtain special instructions before use. 使用前获取专门指示。
  • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P351+P338+P337+P313
  • P308+P313
  • P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
  • P370+P378
  • P403+P233
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
RTECSFD4200000
Packing GroupII
UN Number 2262 UN 2262 8/PG 2 UN2262
Risk Statements
  • R22 Harmful if swallowed 吞咽有害
  • R23 Toxic by inhalation 吸入有毒
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R45 May cause cancer 可能致癌
Safety Statements
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Storage condition +4°C 2-8°C 4 4℃ {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Codes 8 T
Hazard Class8
Warnings 危化品目录(2015) 
TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 8 gm/kg/40W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 894 mg/kg/52W-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   JACTDZ Journal o

TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - hamster
DOSE/DURATION           : 1 ppm/6H/2Y-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 4(1),107,1980

TYPE OF TEST            : TD

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5200 mg/kg/26W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   48,15

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 300 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz.  (Darmstadt, Fed.
   Rep. Ger.)  V.1-25, 1951-75.  Volume(issue)/page/year: 24,71,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
REFERENCE :
   ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz.  (Darmstadt, Fed.
   Rep. Ger.)  V.1-25, 1951-75.  Volume(issue)/page/year: 24,71,1974

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 180 ppm/6H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JEPTDQ Journal of Environmental Pathology and Toxicology.  (Park Forest
   South, IL)  V.1-5(3), 1977-81(?).  For publisher information, see JEPOEC.
   Volume(issue)/page/year: 4(1),107,1980

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1000 mg/m3/10M
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NDRC** National Defense Research Committee, Office of Scientific Research
   and Development, Progress Report.  Volume(issue)/page/year:
   NDCrc-132,OCT1942

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 6(Suppl
   2),1,1984

TYPE OF TEST            : Morphological transformation
TEST SYSTEM             : Rodent - hamster Kidney
DOSE/DURATION           : 80 ug/L
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   37,873,1978

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 540 pmol/tube
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33 ug/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 5(Suppl
   1),3,1983

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 187 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 97,49,1982

TYPE OF TEST            : Si

Restrict 危险品

其他信息

  • 方法一:二甲氨基甲酰氯是由二甲胺与光气反应制得。反应方程式：(CH 3 ) 2 NH+COCl 2 →(CH 3 ) 2 NCOCl 将甲苯加入反应锅内，在冷却的条件下通入光气吸收至计算量。在另一锅中由二甲胺水溶液发生气体二甲胺，经干燥后通入光气甲苯溶液中反应。反应结束后过滤除去盐酸盐，减压蒸馏，收集75℃(3.33kPa)馏分即为二甲氨基甲酰氯，收率55％。 二甲氨基甲酰氯还可由N，N-二甲基甲酰胺与三氯化磷反应后，再与氯化亚砜反应制得。反应方程式如下：HCON(CH 3 ) 2 +PCl 3 →[(CH 3 ) 2 N+=CHOPCl 2 ]Cl - [SOCl 2 ]→(CH 3 )2NCOCl 另外，亦可以Pd、PdCl 2 或RhCl 3 为催化剂，由二甲基氯化铵与一氧化碳反应制得。反应方程式：(CH 3 ) 2 NCl+CO[催化剂]→(CH 3 ) 2 NCOCl
  • 用途二:二甲氨基甲酰氯是氨基甲酸酯类杀虫剂如抗蚜威、唑蚜威等的中间体，也用作医药、染料、合成材料及其他精细化学品的中间体，如用于生产溴化新斯的明、甲基硫酸新斯的明、吡啶斯的明等。
  • MOL 文件:79-44-7.mol
  • 用途一:用作医药、农药中间体
  • 图谱信息:二甲氨基甲酰氯(79-44-7)质谱(MS) 二甲氨基甲酰氯(79-44-7)Raman光谱 二甲氨基甲酰氯(79-44-7)核磁图( 13 CNMR) 二甲氨基甲酰氯(79-44-7)红外图谱(IR1)
  • 敏感性:Moisture Sensitive
  • MSDS 信息:二甲基氨基甲酰氯(79-44-7).msds
  • 下游产品:N-4-异丙基苯基-N',N'-二甲基脲 --> 2-氰基吡啶-4-醛 --> 4-甲基-2-羧酸吡啶 --> 2-氰基吡啶-4-羧酸乙酯 --> 4-羟甲基吡啶-2-腈 --> 1,4,5,8-萘四甲酸 --> 偶氮二甲酰胺 --> 灭蚜松粉剂、可湿性粉剂、拌种剂 --> 1-(2-吡啶-2-基乙基)哌嗪 --> 3-(N,N-二甲氨基甲酰氧基)吡啶 --> 哌嗪-1-羧酸二甲胺 --> 溴化新斯的明
  • F:9
  • 上游原料:氯 --> 二甲胺 --> 一氧化碳 --> 冶金焦 --> 二甲胺水溶液 --> 氯胺 T
  • 外观性质:无色透明液体。
  • 用途三:用作医药、农药、染料、塑料、合成材料及其他精细有机化工产品的合成，例如用于生产溴化新期的明、甲基硫酸新斯的明、吡啶斯的明，氨基甲酸酯类杀虫剂等。
  • 方法二:以二甲胺为原料，与光气进行甲酰氯化反应，得二甲基甲酰氯胺粗品，经脱酸而得成品。
  • Sigma Aldrich:79-44-7(sigmaaldrich)
  • 二甲氨基甲酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 D0695 二甲基氨基甲酰氯 Dimethylcarbamoyl Chloride 500G 982元 2014/06/02 D0695 二甲基氨基甲酰氯 Dimethylcarbamoyl Chloride 25G 206元 2010/05/25 L03415 二甲氨基甲酰氯, 96% Dimethylcarbamyl chloride, 96% 25g 238元
  • TCI Shanghai:N,N-二甲基氨基甲酰氯 Dimethylcarbamoyl Chloride,>;97.0%(GC)(79-44-7)
  • Alfa Aesar:二甲氨基甲酰氯,96% Dimethylcarbamyl chloride, 96%(79-44-7)
  • 溶于乙醚、二硫化碳和苯等有机溶剂。遇水分解。

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Protection and Derivatization - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Halogenated Hydrocarbons 卤代烃
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Functional Group 官能团索引
  2. CO2 derivative (general)
  1. Functional Group 官能团索引
  2. carbonic acid derivative
  1. carbamic acid halide (haloformic acid amide)

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