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• {SNA} β-Glucuronidase Drug Analysis Bundle, Alkyl, Analytical and Industrial Enzymes, Building Blocks, Chemical Synthesis, Halogenated Hydrocarbons, IOD - Iodomethane, Organic Building Blocks, 生化试剂, 酶、抑制剂和底物
• Alphabetic, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Environmental Standards,

相关文献及参考

• Merck 14 ,6087
• Beil. 1 ,IV,87
• Short: II/14a Title: Molecular Constants: Diamagnetic Molecules Author: Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14a Page: 1-788 Year: 1982 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-11365-7 ISBN: 978-3-540-11365-2 Internet Resource: DOI:10.1007/b19966 RefComment: 196 figs., XI
• Short: II/14b Title: Molecular Constants: Radicals, Diatomic Molecules and Substance Index Author: Brown, J.M.; Demaison, J.; Dubrulle, A.; Hüttner, W.; Tiemann, E. Editor: Hellwege, K.-H.; Hellwege, A.M. Source: Landolt-Börnstein, New Series Volume: II/14b Page: 1-373 Year: 1983 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy; radicals ISBN: 3-540-11857-8 ISBN: 978-3-540-11857-2 Internet Resource: DOI:10.1007/b19967 RefComment: 196 figs., IX
• Short: II/19a Title: Molecular Constants: Rotational, l-type, Centrifugal Distortion and Related Constants of Diamagnetic Diatomic, Linear, and Symmetric Top Molecules Author: Demaison, J.; Hüttner, W.; Tiemann, E.; Wlodarczak, G. Editor: Hüttner, W. Source: Landolt-Börnstein, New Series Volume: II/19a Year: 1992 Keyword: organic compounds; molecular constants; spectroscopy; microwave spectroscopy ISBN: 3-540-54409-7 ISBN: 978-3-540-54409-8 Internet Resource: DOI:10.1007/b42304 RefComment: XI, 143 pages. Abstract: Volume II/19 Molecular Constants mostly from Microwave, Molecular Beam and Sub-Doppler Laser Spectroscopy is a supplement to the earlier volumes II/4, II/6, and II/14. The slight change in the title reflects current trends in the applications of spectroscopic methods. Together, the four volumes collect all the critically evaluated data published up to 1989/90 on constants of free molecules obtained by classical and modern spectroscopy. Volume

安全信息

GHS Symbol

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - colon tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   ZEKBAI Zeitschrift fuer Krebsforschung.  (Berlin, Fed. Rep. Ger.)  V.1-75,
   1903-71.  For publisher information, see JCROD7.  Volume(issue)/page/year:
   74,241,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 44 mg/kg/8W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Lungs, Thorax, or Respiration - tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   35,1411,1975

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5 gm/m3/57M-C
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BJIMAG British Journal of Industrial Medicine.  (British Medical Journal,
   Box 560B, Kennebunkport, ME 04046)  V.1-    1944-  Volume(issue)/page/year:
   7,122,1950

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 51 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,84,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 101 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 198

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 794 mg/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - other changes
   Gastrointestinal - other changes
   Blood - hemorrhage
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 20 umol/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   46,277,1980

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 2 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 136,137,1984

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 50 mg/L/4H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 59,61,1979

TYPE OF

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 ug/disc
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,873,1979

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 3600 ug/L
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1000 ppm
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,901,1979

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其他信息

• 实验室制备碘甲烷:在甲醇与红磷的混合物中加入碘时，会发生放热反应而生成碘甲烷：5 CH3OH + P + 2.5 I2 → 5 CH3I + H3PO4 + H2O 反应中生成了三碘化磷中间体，起到了与甲醇发生碘化反应的作用。 碘甲烷也可由硫酸二甲酯与碘化钾在碳酸钙存在下反应制得：(CH3O)2SO2 + KI → K2SO4 + 2 CH3I 先将反应产物蒸馏，然后用Na2S2O3、水和Na2CO3溶液洗涤，便可得到纯净的碘甲烷。
• 外观性质:无色液体，有特臭。
• MSDS 信息:碘甲烷(74-88-4).msds
• {Chemicalbook
• 用途二:用作分析试剂，也用于制药工业
• 毒性分级:高毒
• 下游产品:6-甲基-3-甲氧基-2-碘吡啶 --> 哌唑嗪 --> 4-甲基-2-甲硫基嘧啶 --> 2-甲基-5-甲氧基吡啶 --> 2,2-二甲基环戊酮 --> 克拉霉素 --> 2-甲硫基-4-氯-5-溴嘧啶 --> 2-甲基-2H-吲唑-3-甲酸 --> 2-甲硫基-4-苯甲氨基嘧啶 --> (S)-(-)-环氧丙基甲基醚 --> 2-甲硫基-4-氯嘧啶 --> 2-溴-3-甲氧基-6-甲基吡啶 --> 轻水泡沫灭火剂 FC-4 --> 4-氯-N-甲基嘧啶-2-胺 --> (1-甲基-1H-苯并眯唑-2-基)甲胺 --> 2,2-二甲基环己酮 --> 阿司咪唑 --> 3-甲基-4-硝基苯甲醚 --> (R)-(-)-环氧丙基甲基醚 --> 2-甲硫基-4,6-二甲基嘧啶 --> 7-甲氧基香豆素 --> 新戊基碘 --> 轻水泡沫灭火剂 FC-3 --> 1-(2-二甲基氨基乙基)-1H-5-巯基-四氮唑 --> 3Β,17Β-二羟基孕甾-5-烯-21-羧酸 --> 坎利酮 --> 2-苯基-2-丙醇 --> 3Β,17Β-二羟基孕甾-5-烯-21-羧酸-Γ-内酯 --> 美雄醇 --> 5-巯基-1,2,3,4-四氮唑-1-甲基磺酸 --> 2-乙酰基-3-甲基吡嗪 --> 3Β,17Β-二羟基雄甾-5-烯-17Α-丙炔酸 --> 碘化1,2-二甲基吡啶鎓 --> 雄甾-5-烯-3,17-二醇-17-丙炔酸钾盐 --> 苄基三甲基碘化铵
• 图谱信息:碘甲烷(
• Acros Organics:碘甲烷 Iodomethane,stabilized,99%(74-88-4)
• F:8
• 甲基化反应:碘甲烷与碳酸二甲酯、硫酸二甲酯、三氟甲磺酸甲酯是常见的甲基化试剂 根据软硬酸碱理论，碘是“软”的阴离子，因而碘甲烷所参与的甲基化反应也应在两位亲核试剂较“软”的一段发生。比如，在与硫氰酸根离子反应时，S更软，因而从S原子进攻的可能性较从N原子进攻的可能性大，产物主要是硫氰酸甲酯（CH3SCN）而非CH3NCS。而且，碘甲烷与1,3-二羰基化合物生成的烯醇盐之间发生的反应也可用以上理论来解释。相对于碳原子，氧原子较硬，碘甲烷参与的反应也几乎都生成C-甲基化的产物。 碘甲烷甲基化具有以下一些缺点： 它相对分子质量较大，一摩尔MeI的质量几乎等于三摩尔CH3Cl的质量； 碘化合物较氯化物和溴化物仍显得比较昂贵，因而在工业上更加便宜的硫酸二甲酯仍有不少应用，尽管它的毒性比碘甲烷要高出很多； 碘离子离去基团可能会造成副反应； 碘甲烷的毒性比相应的氯化合物和溴化合物要大，对生产工人很不利。 因此在选择甲基化试剂时，通常要均衡考虑价格、来源、毒性、化学选择性及反应容易程度等诸多因素。
• 用途一:主要用作甲基化试剂，在医药工业中用于碘甲基蛋氨酸(维生素U)、镇痛药、解毒药磷酸系药物的生产
• 概述:碘甲烷是一个卤代烃，分子式为CH3I、MeI，是甲烷的一碘取代物。沸点42.4℃，相对密度2.279（20/4℃），室温下为密度大的挥发性液体，偶极矩1.59D，折射率1.5304（20°C、D）、1.5293（21°C、D）。碘甲烷可与常见的有机溶剂混溶，微溶于水，溶于乙醇、乙醚，纯品无色，特臭，暴露于阳光下会分解出I2而带紫色，可通过加入金属铜
• 急性毒性:吸入-大鼠LC50: 1300毫克/立方米/4小时; 腹腔-小鼠LD50:172 毫克/ 公斤
• 用途三:医药工业用于碘甲基蛋氨酸（维生素U）、镇痛