Isophthaloyl chloride 间苯二甲酰氯

CAS 99-63-8 MFCD00000678

化学结构图

99-63-8
SMILES: O=C(Cl)c1cccc(C(=O)Cl)c1

化学属性

Mol. FormulaC₈H₄Cl₂O₂
Mol. Weight203.02
Density1.38
Boiling Point
Vapor Pressure0.03 mmHg ( 25 °C)
Melting PointNo Data Available
Flash Point180°(356°F)
TSCAYes
Solubility起反应
Stability对湿度和光敏感

别名和识别编码

Chemical NameIsophthaloyl chloride
CAS Number99-63-8
EC Number202-774-7
Beilstein Registry Number638342
MDL NumberMFCD00000678
Synonym Isophthaloyl Chloride {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID7451
Reaxys-RN638342
Chemical Name Translation间苯二甲酰氯
Wiswesser Line NotationGVR CVG
LabNetwork Molecule IDLN00224126
InChIInChI=1S/C8H4Cl2O2/c9-7(11)5-2-1-3-6(4-5)8(10)12/h1-4H
Canonical SMILESClC(C1=CC(C(Cl)=O)=CC=C1)=O
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分类

  • {uni_hamburg} no charge; carbocycle; aromatic; 6RingOnly; 6ring; carbonyl chloride; 1fragment
  • {SNA} Carboxylic Acid Monomers, Materials Science, Monomers, Polymer Science
  • {SNA} Acid Halides, Building Blocks, Carbonyl Compounds, Chemical Synthesis, Organic Building Blocks
  • {SNA} Carboxylic Acid Monomers, Chemical Synthesis, Development Quantities for Research, Materials Science, Monomers, Polymer Science
  • {SNA} Carboxylic Acid Monomers, Chemical Synthesis, Development Quantities for Research, Monomers, Polymer Science, 材料科学

产品应用

  • 间苯二甲酰氯可用作芳香类纤维类的原料。

相关文献及参考

  • Beilstein:9,834
  • Short: III/31a
  • Short: III/38B

安全信息

Signal word Danger
GHS Symbol
WGK Germany1
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
  • S7/8 Keep container tightly closed and dry 保存在严格密闭容器中，保持干燥；
Risk Statements
  • R21 Harmful in contact with skin 与皮肤接触有害
  • R23 Toxic by inhalation 吸入有毒
  • R34 Causes burns 会导致灼伤
  • R35 Causes severe burns 会导致严重灼伤
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R37 Irritating to respiratory system 刺激呼吸道
Precautionary statements
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P304+
  • P304+P340
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H331 Toxic if inhaled 吸入中毒
  • H312 Harmful in contact with skin 皮肤接触有害
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
RTECSNT2625000
Packing GroupI
UN Number 2923 UN 3261 8/PG 2
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Hazard Codes 8 C T
Hazard Class8
Warnings 危化品目录(2015) 危险化学品 
TYPE OF TEST            : LC - Lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >31 gm/m3/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0533736

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2221 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(7),75,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1175 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - food intake (animal)
   Behavioral - changes in motor activity (specific assay)
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 47(7),75,1982

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1410 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, M

其他信息

  • 遇水、醇分解，溶于醚和其它有机溶剂。
  • 毒性分级:低毒
  • 外观性质:白色或浅黄色结晶固体。
  • 用途二:可用于合成芳纶、聚丙烯酸酯、耐高温树脂、染料、颜料、医药以及农药等
  • 可燃性危险特性:可燃; 遇水放出有毒氯化氢气体
  • Acros Organics:间苯二甲酰氯 Isophthaloyl dichloride, 98%(99-63-8)
  • 上游原料:氧氯化硫 --> 五氯化磷 --> 间苯二甲酸二甲酯
  • 刺激数据:皮肤-兔子 200 毫克 中度; 眼睛-兔子 40 毫克 轻度
  • 间苯二甲酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 I0159 间苯二酰二氯 Isophthaloyl Chloride 25G 177元 2014/06/02 I0159 间苯二酰二氯 Isophthaloyl Chloride 500G 676元 2010/06/21 122661000 间苯二甲酰氯 Isophthaloyl dichloride 98% 100 GR 237元
  • TCI Shanghai:间苯二酰二氯 Isophthaloyl Chloride,>;99.0%(GC)(T)(99-63-8)
  • 方法一:有氯化亚砜法、五氯化磷法、光气法、间苯二甲酸二甲酯氯化法、间苯二甲酸氯化法。较多采用光气法，通常在甲酰胺系催化剂存在下进行光气化反应。如果先使间苯二甲酸转变成分子间酸酐，然后进行光气化反应，间苯二甲酰氯本身双作为反应溶剂使用，可以获得较高收率。
  • Alfa Aesar:间苯二甲酰氯,98% Isophthaloyl dichloride, 98%(99-63-8)
  • 下游产品:苯乙双胍 --> 乙嘧替氟
  • MOL 文件:99-63-8.mol
  • 蒸气压:0.03 mm Hg ( 25 °C)
  • 灭火剂:砂土、干粉、二氧化碳
  • 类别:腐蚀物品
  • 海关编码:29173940
  • 急性毒性:口服-大鼠 LD50: 2200 毫克/公斤; 口服-小鼠 LD50: 2221 毫克/公斤
  • MSDS 信息:间苯二甲酰氯(99-63-8).msds
  • Sigma Aldrich:99-63-8(sigmaaldrich)
  • F:21
  • 用途三:间苯二甲酰氯可用作芳香类纤维类的原料。
  • 储运特性:库房通风低温干燥; 与碱、氧化剂分开存放
  • 用途一:用作农药、医药、高分子中间体
  • 敏感性:Moisture Sensitive

系列性分类

  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Carbonyl Compounds 羰基化合物
  5. Acid Halides 酸性卤化物(酰氯等)
  1. Materials Science 材料科学
  2. Products for Polymer Science Research
  3. Monomers - Polymer Science
  4. Carboxylic Acid Monomers - Monomers
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Monomers
  4. Bisphenol and Sulfonyldiphenol Monomers
  1. Acyl halide
  2. acyl chloride

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