Acryloyl chloride 丙烯酰氯

CAS 814-68-6 MFCD00000731

化学结构图

814-68-6
SMILES: C=CC(=O)Cl

化学属性

Mol. FormulaC3H3ClO
Mol. Weight90.51
Refractive index1.4330 to 1.4350
Boiling Point72-76
Density1.114
Flash Point16°C(lit.)
TSCAYes
Vapor Density>;1 (vs air)
Vapor Pressure1.93 psi ( 20 °C)
Solubility可混溶于氯仿。
Stability对光线和热敏感,易吸潮

别名和识别编码

Chemical NameAcryloyl chloride
Synonym 2-PROPENOYL CHLORIDE 2-Propenoyl chloride 2-propenoyl chloride ACRYLIC ACID CHLORIDE ACRYLOYL CHLORIDE ACRYLOYL CHLORIDE STAB. WITH 2 6-DI-TER ACRYLOYL CHLORIDE, 96%, STABILIZED ACRYLOYL CHLORIDE, STAB. Acrylic acid chloride Acrylic acidchloride Acryloyl Chloride Acryloyl Chloride (stabilized with Phenothiazine) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number814-68-6
PubChem Substance ID13140
EC Number212-399-0
Beilstein Registry Number635744
MDL NumberMFCD00000731
Reaxys-RN635744
Chemical Name Translation丙烯酰氯
Wiswesser Line NotationGV1U1
LabNetwork Molecule IDLN00226341
InChIInChI=1S/C3H3ClO/c1-2-3(4)5/h2H,1H2
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分类

  • Acrylate, Acrylic Monomers, Materials Science, Monomers, Polymer Science
  • {uni_hamburg} no charge; carbonyl chloride; 1fragment
  • {SNA} Acrylate, Acrylic Monomers, Materials Science, Monomers, Polymer Science

产品应用

  • 有机合成中间体。高分子化合物单体。

相关文献及参考

  • Short: II/24C
  • Short: II/24B
  • Beilstein:2(4)1471

安全信息

GHS Symbol
WGK Germany3
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H290 May be corrosive to metals 可能腐蚀金属。
  • H302 Harmful if swallowed 吞食有害
  • H312 Harmful in contact with skin 皮肤接触有害
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H330 Fatal if inhaled 吸入致命
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
Hazard Codes 6.1 F,T+
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P234 Keep only in original container. 只保留在原来的容器中。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
  • P241+P242+P243
  • P242 Use only non-sparking tools. 只能使用无火花工具。
  • P243 Take precautionary measures against static discharge. 采取预防措施,防止静电放电。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P264+P265
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P301+P312
  • P301+P317
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P352
  • P302+P361+P354
  • P303+P361+P353
  • P304+P340
  • P304+P340+P310
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P316
  • P317
  • P320 Specific treatment is urgent (see … on this label). 紧急具体治疗(见本标签上的)。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P322 Specific measures (see …on this label). 具体治疗(见本标签上的)。
  • P330 Rinse mouth. 漱口
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P370+P378
  • P390 Absorb spillage to prevent material damage. 吸收溢出物,防止重大损害。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403+P233
  • P403+P235
  • P404 Store in a closed container. 贮存于密闭容器中。
  • P405 Store locked up. 上锁保管。
  • P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger
RTECSAT7350000
UN Number 3383 3488 UN 3383 6.1/PG 1 UN3383
Storage condition -20°C 0-10 0-10°C 2-8°C 2-8°C储存 Moisture & Light Sensitive 储存温度2-8℃,充氩保存
Risk Statements
  • R11 Highly flammable 非常易燃
  • R14 Reacts violently with water 遇水会猛烈反应
  • R26 Very toxic by inhalation 吸入极毒
  • R34 Causes burns 会导致灼伤
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S20 When using do not eat or drink 使用时,不得进食,饮水;
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
  • S30 Never add water to this product 切勿将水加入该产品中;
  • S33 Take precautionary measures against static discharges 对静电采取预防措施;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S4 Keep away from living quarters 远离生活区;
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
  • S7/9 Keep container tightly closed and in a well-ventilated place 保持容器严格密闭,置于通风良好的场所;
  • S8 Keep container dry 保持容器干燥;
  • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Packing GroupI
Hazard Class6.1/3, 8
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03367

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 ppm/4H
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - iritis
   Behavioral - ataxia
   Lungs, Thorax, or Respiration - emphysema
REFERENCE :
   BJIMAG British Journal of Industrial Medicine.  (British Medical Journal,
   Box 560B, Kennebunkport, ME 04046)  V.1-    1944-  Volume(issue)/page/year:
   27,1,1970

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 92 mg/m3/2H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,17,1982

其他信息

  • 海关编码:29161980
  • 外观性质:浅黄色液体。
  • Alfa Aesar:丙烯酰氯,96%,400ppm的苯并噻嗪作稳定剂 Acryloyl chloride, 96%, stab. with 400ppm phenothiazine(814-68-6)
  • Sigma Aldrich:814-68-6(sigmaaldrich)
  • 类别:有毒物品
  • 用途三:有机合成中间体。高分子化合物单体。
  • 丙烯酰氯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 L1036302 丙烯酰氯, 96% 50g 319元 2011/04/16 A0147 丙烯酰氯(含稳定剂吩噻嗪) Acryloyl Chloride (stabilized with Phenothiazine) 500G 2880元 2011/04/16 A0147 丙烯酰氯(含稳定剂吩噻嗪) Acryloyl Chloride (stabilized with Phenothiazine) 25G 374元
  • 敏感性:Moisture & Light Sensitive
  • TCI Shanghai:丙烯酰氯(含稳定剂甲氧基氢醌) Acryloyl Chloride (stabilized with MEHQ),>;95.0%(T)(814-68-6)
  • 用途二:该品用于有机合成。国外市售98%商品,沸点72-76℃,相对密度1.114,闪点16℃。
  • 上游原料:氯化亚铜
  • 储运特性:库房通风低温干燥
  • 用途一:主要用于合成丙烯酸酯、丙烯酰胺类化合物,也用于制备防灰雾剂I的中间体
  • 蒸气密度:>;1 (vs air)
  • 图谱信息:丙烯酰氯(814-68-6)核磁图( 13 CNMR) 丙烯酰氯(814-68-6)核磁图( 1 HNMR) 丙烯酰氯(814-68-6)质谱(MS) 丙烯酰氯(814-68-6)红外图谱(IR1)
  • MOL 文件:814-68-6.mol
  • 易溶于氯仿,遇水和醇分解。有毒。有催泪性和腐蚀性。商品常加吩噻嗪和对苯二酚作稳定剂。
  • 蒸气压:1.93 psi ( 20 °C)
  • 毒性分级:高毒
  • 下游产品:N-异丙基丙烯酰胺 --> 苯磺酸阿曲库铵 --> N-丙烯酰氧基琥珀酰亚胺 --> 1,4-二丙烯酰基哌嗪 --> 1,4-丁二醇二丙烯酸酯
  • 可燃性危险特性:可燃; 加热分解释放有毒氯化物烟雾
  • 方法一:由丙烯酸和三氯化磷作用,丙烯酸与三氯化磷的摩尔配比为1:0.333,将两者混合后,加热至沸腾。将反应混合物慢慢冷却到60-70℃。再反应15min,然后在室温下放置2h。反应物分二层,分出上层产物,加入氯化亚铜进行减压蒸馏,收集30-40℃(18.7kPa)的馏分,重蒸一次,收集30-32℃(18.7kPa)的馏分,得到丙烯酰氯。产率66%。
  • MSDS 信息:丙烯酰氯(814-68-6).msds
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • F:8-10
  • 急性毒性:吸入-大鼠 LCL0:25 PPM/4小时; 吸入-小鼠 LC50: 92 毫克/立方米/2小时

系列性分类


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