L(+)-Arginine L-精氨酸

CAS 74-79-3 MFCD00002635

化学结构图

74-79-3
SMILES: N=C(N)NCCC[C@H](N)C(=O)O

化学属性

Mol. FormulaC6H14N4O2
Mol. Weight174.20
Melting Point222°C
Density1.46
TSCAYes
SolubilitySoluble in water (50 mg/ml), and alcohol (sparingly). Insoluble in ether.,
Refractive index27.1°
Stability对光敏感
Appearance +27.3°(0.5-2.0mg/ml,6mol/L HCl);水溶液在205nm处有最大吸收(1gε3.28)。 D 20 白色菱形结晶 (从水中析出,含2分子结晶水)或单斜片状结晶(无结晶水),无臭,味苦;易溶于水(0℃水中溶解度为83g/L,50℃水中溶解度为 400g/L),极微溶于乙醇,不溶于乙醚;pI6.0;加热至105℃时失去两分子结晶水,230℃时颜色变深,分解点为244℃;比旋光度[α] powder +12.5°(0.5-2.0mg/ml,H2O),[α]
Boiling Point409.1°C at 760 mmHg

别名和识别编码

Chemical NameL(+)-Arginine
CAS Number74-79-3
Alfabeta NameARGININE L-
MDL NumberMFCD00002635
Synonym L-Arginine {LY} L-Arginine {} {LY} L-Arginine {} {} {LY} L-Arginine {} {} {} {LY} L-Arginine {} {} {} {} {LY} L-Arginine {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} L-Arginine {} {} {} {} {} {} {} {} {}
Beilstein Registry Number4(4)2648
EC Number200-811-1
Reaxys-RN1725413
PubChem Substance ID87562132
Merck Number780
Chemical Name TranslationL-精氨酸
InChIKeyODKSFYDXXFIFQN-BYPYZUCNSA-N
LabNetwork Molecule IDLN00146375
InChIInChI=1S/C6H14N4O2/c7-4(5(11)12)2-1-3-10-6(8)9/h4H,1-3,7H2,(H,11,12)(H4,8,9,10)/t4-/m0/s1
Canonical SMILESN[C@@H](CCCNC(N)=N)C(O)=O
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分类

  • {SNA} Analytical Standards, Analytical/Chromatography, Chromatography, EP Standards, EP Standards A - B, Pharmaceutical Standards,
  • {SNA} Allium cepa (Onion), Allium sativum (Garlic), Aloe Vera, Amino Acid, Amino Acids, Amino Acids & Derivatives, Amino acids, Application Index, Arginine, Arginine Metabolism, Armoracia rusticana (Horseradish), Cell Signaling Enzymes, Chemical Biology, Chemical Synthesis, Cichorium intybus (Chicory), Core Bioreagents, Functional Foods, Ginkgo biloba, Humulus lupulus (Hops),
  • {SNA} Allium cepa (Oni
  • {SNA} A-F,

产品应用

  • 一氧化氮合成酶底物,能转换为瓜氨酸和NO。靠一种依赖于NO的机制诱导胰岛素分泌。

相关文献及参考

  • [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.
  • [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.
  • Merck 14 ,780
  • Merck: 14,780
  • Merck: 14,780 Beilstein:4(4)2648
  • [1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.
  • [1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.
  • [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72

安全信息

Warnings IRRITANT
WGK Germany1
RTECSCF1934200
Signal word Warning
GHS Symbol
Safety Statements
  • S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
Risk Statements
  • R36 Irritating to eyes 刺激眼睛
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P305+P351+P338
Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {}
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - grasshopper
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   IJEBA6 Indian Journal of Experimental Biology.  (Publications & Information
   Directorate, CSIR, Hillside Rd., New Delhi 110 012, India)  V.1-    1963-
   Volume(issue)/page/year: 24,460,1986

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 372,75,1996

其他信息

  • 用途三:营养增补剂;调味剂。 与糖进行加热反应(氨基
  • 毒性分级:中毒
  • {Chemical
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量(g/
  • Acros Organics:L-精氨酸 L(+)-Arginine, 98+%(74-79-3)
  • 方法三:以明胶或猪毛、猪血粉等为原料,经水解后,从水解液中提取氨酸盐酸盐(见03400),再经脱盐酸而得成品。
  • 下游产品:L-苯丙氨酸 --> L-胱氨酸 --> 亮丙瑞林 --> L-精氨酸盐酸盐 --> 胍立莫司 --> 阿加曲班 -
  • 图谱信息:L-精氨酸(74-79-3)质谱(MS) L-精氨酸(74-79-3)红外图谱(IR2) L-精氨酸(74-79-3)红外图谱(IR1) L-精氨酸(74-79-3)核磁图( 1 HNMR) L-精氨酸(74-79-3)核磁图( 13 CNMR)
  • {Ch
  • 灭火剂:干粉,泡沫,沙土,二氧化碳, 雾状水
  • 类别:有毒物品
  • 方法二:以明胶为原料,盐酸水解后与苯甲醛缩合得苯亚甲基精氨酸,经盐酸水解、活性炭处理、柱层析精
  • 用途一:用作医药原料及食品添加剂
  • 从乙醇中析出的为无水单斜片状结晶。溶于水,微溶于乙醇,不溶于乙醚。具强碱性,水溶液能从空气中吸收二氧化碳。
  • 方法二:以明胶为原料,盐酸水解后与苯甲醛缩合得苯亚甲基精氨酸,经盐酸
  • 鉴别试验:取0.1%试样液5ml,加水合茚三酮试液(TS-250)lml,应呈红紫色。
  • 急性毒性:参考值: 腹腔-大鼠 LD50: 3793 毫克/公斤
  • L-精氨酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 62004036 L-精氨酸 100g 105元 2011/04/16 A0526 L-(+)-精氨酸 L-(+)-Arginine 25G 146元 2011/04/16 A0526 L-(+)-精氨酸 L-(+)-Arginine 500G 1220元
  • FEMA:3819
  • MOL 文件:74-79-3.mol
  • 使用限量:占食品中总蛋白质量的6.6%(FDA§172.320,2000)。 FEMA(mg/kg):焙烤制品、早餐谷物,20~100;无醇饮料、含醇饮料,3~30;干酪、酱汁、肉制品、果仁制品、禽制品,15~100;胶姆糖、糖果、糖霜、凝胶及布丁、软糖、代糖品、甜沙司,3
  • 所属类别一:食品添加剂: 营养强化剂(营养增补: 氨基酸
  • 参考质量标准二:含量大于99.5%;比旋光度[α] 25 D +25°-27°;氯化物(以Cl计)含量小于0.02%,硫酸盐(以SO 2- 4^计)含量小于0.02%,重金属(以Pb计)含量小于0.001%;标准品高效液相色谱呈单峰。
  • 检测方法:NMR,Rotation
  • 用途五:一氧化氮合成酶底物,能转换为瓜氨酸和NO。靠一种依赖于NO的机制诱导胰岛素分泌。
  • 用途二:用于生化研究,各类肝昏迷及病毒性肝类谷丙转氨酶异常者。
  • 所属类别二:生物化学品: 生化试剂: 氨基酸及其衍生物
  • 可燃性危险特性:可燃; 燃烧产生有毒氮氧化物烟雾
  • 储运特性:库房通风低温干燥
  • 用途四:氨基酸类药。
  • L-Arginine is an essential amino acid and precursor of nitric oxide synthesis that induces vasodilation in vivo. Nitric oxide potentiates insulin-mediated glucose uptake through the increase in blood flow.

系列性分类