Sodium chloroacetate 氯乙酸钠
CAS 3926-62-3 MFCD00002684
化学结构图
SMILES: O=C([O-])CCl.[Na+]
化学属性
| Mol. Formula | C₂H₂ClNaO₂ |
|---|---|
| Mol. Weight | 116.48 |
| Density | 1.399 |
| Melting Point | >210°C (dec.) |
| Flash Point | - |
| TSCA | Yes |
| Solubility | 440 G/L (20 ºC) |
| Stability | 易吸潮 |
| Boiling Point |
别名和识别编码
| Chemical Name | Sodium chloroacetate |
|---|---|
| Synonym | Sodium a-Chloroacetate {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { |
| MDL Number | - |
| CAS Number | 3926-62-3 |
| EC Number | 223-498-3 |
| Beilstein Registry Number | 3597157 |
| Merck Number | 14,2112 |
| PubChem Substance ID | 23665759 |
| Chemical Name Translation | 氯乙酸钠 |
| Wiswesser Line Notation | QV1G &-NA- |
| LabNetwork Molecule ID | LN00221588 |
| InChI | InChI=1S/C2H3ClO2.Na/c3-1-2(4)5;/h1H2,(H,4,5);/q;+1/p-1 |
| Canonical SMILES | O=C([O-])CCl.[Na+] |
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分类
- {SNA} Chemical Synthesis, Essential Chemicals, Inorganic Salts, Research Essentials, Salts, Sodium, Sodium Salts, Synthetic Reagents
- {uni_hamburg} no charge; carboxylate; 2fragments; ionic
- {SNA} Chemical Synthesis, Inorganic Salts, Sodium, Synthetic Reagents
产品应用
- 有机合成。药用。除草剂。染料。
相关文献及参考
- Merck: 14,2112
- Short: III/20a
- Short: IV/1a
- A convenient method for the conversion of arylamines to the corresponding N,N-diacetic acids is by lithiation followed by reaction with sodium chloroacetate. For discussion and limitations, see: Sy
- Short: EINECS
- A convenient method for the conversion of arylamines to the corresponding N,N-diacetic acids is by lithiation followed by reaction with sodium chloroacetate. For discussion and limitations, see: Synthesis, 548 (1989).
- Merck: 14,2112 Beilstein: 2,IV,478
安全信息
GHS Symbol
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S37 Wear suitable gloves 戴适当手套；
- S22 Do not breathe dust 不要吸入粉尘；
- R25 Toxic if swallowed 吞咽有毒
- R38 Irritating to skin 刺激皮肤
- R36 Irritating to eyes 刺激眼睛
- R50 Very toxic to aquatic organisms 对水生生物极毒
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
- P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
- P273 Avoid release to the environment. 避免释放到环境中。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P310
- P301+P312
- P302+P352
- P304+P340
- P305+P351+P338
- P308+P313
- P309+P311
- P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
- P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
- P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
- P330 Rinse mouth. 漱口
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
- P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
- P403+P233
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H301 Toxic if swallowed 吞食有毒
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Mammal - species unspecified DOSE/DURATION : 150 mg/kg TOXIC EFFECTS : Behavioral - muscle contraction or spasticity Gastrointestinal - hypermotility, diarrhea Lungs, Thorax, or Respiration - dyspnea REFERENCE : NVTMAF Nordisk Veterinaermedicin Danske Udgave. (Copenhagen, Denmark) Volume(issue)/page/year: 13,271,1961
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 165 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 86,336,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 95 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 23,78,1941
TYPE OF TEST
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - guinea pig DOSE/DURATION : 99 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/
其他信息
- 可燃性危险特性:可燃； 燃烧产生有毒氯化物和氧化钠烟雾
- 氯乙酸钠价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 LA1237902 氯乙酸钠;氯醋酸钠 500g 220元 2011/08/23 80116326 氯乙酸钠;氯醋酸钠 100g 28.9元 2010/06/21 404410025 氯乙酸钠 Chloroacetic acid sodium salt 98% 2.5 KG 715元
- 海关编码:29154000
- 急性毒性:口服- 大鼠 LD50: 95 毫克/公斤;口服- 小鼠 LD50: 165 毫克/ 公斤
- 无气味。溶于水(20℃ 85g/100ml)，微溶于甲醇，不溶于乙醚、苯、丙酮和四氯化碳。中等毒，半数致死量(大鼠，经口)95mg/kg。有刺激性。
- 外观性质:白色粉末或结晶。
- 用途五:有机合成。药用。除草剂。染料。
- Acros Organics:氯乙酸钠 Chloroacetic acid sodium salt, 98%(3926-62-3)
- 用途四:用于农药、医药等有机合成中。
- 用途二:用于染料合成，还用作除草剂
- MSDS 信息:一氯乙酸钠(3926-62-3).msds
- Alfa Aesar:氯乙酸钠,98% Sodium chloroacetate, 98%(3926-62-3)
- 敏感性:Hygroscopic
- 用途三:用于合成染料、农药除草剂等
- 上游原料:氯乙酸
- 用途一:用于医药、化工等
- 类别:腐蚀物品
- MOL 文件:3926-62-3.mol
- 方法一:由氯乙酸与氢氧化钠（或碳酸钠）反应而得。将氯乙酸溶解于无水乙醇中，冷却至20℃以下，慢慢加入氢氧化钠饱和溶液。反应完毕，冷却析出结晶。过滤，用乙醇洗涤，减压蒸馏，干燥而得成品。一般有机合成中只需要氯乙酸钠的水溶液。在这种情况下，将氯乙酸水溶液和碳酸钠于70℃反应，使反应pH为6.8-7，即得所需的氯乙酸钠溶液。
- 灭火剂:砂土、雾状水
- 下游产品:氰乙酸乙酯 --> 丙二酸二乙酯 --> 丙二酸 --> 硝基甲烷 --> 丙二酸二甲酯 --> 乙二胺四乙酸 --> 氰乙酸 --> 羧甲基纤维素 --> 亚氨基二乙酸 --> 稻瘟灵 --> 2,2-二溴-3-次氮基丙酰胺 --> 2,4-二氯苯氧乙酸 --> 依帕斯他 --> 次氮基三乙酸 --> 椰油酰胺基丙基甜菜碱 --> 2,4-二氯苯氧丁酸 --> XCG-CA-2椰油基羧甲基钠型醋酸盐 --> N-甲基亚氨二乙酸 --> 十二烷基二甲基甜菜碱 --> N,N-二甲基-N-十二烷基硫代亚丙基甜菜碱 --> 油酸肌氨酸钠 --> 甜菜碱 --> 脂肪醇聚氧乙烯醚羧酸盐 --> 氰乙酸正丁酯 --> N-十四烷基甘氨酸钠盐 --> N-月桂酰基-N'-羟乙基-羧丙基乙二胺丙酸内盐 --> 甘油醚羧酸盐 --> N-蓖麻油酰基-N-羟乙基-N-羧乙基乙二胺乙酸内盐 --> 2,4-滴丁酯 --> 二甲基烷基甜菜碱 --> 羧甲淀粉钠 --> 还原红 41 --> 椰油酰胺丙基甜菜碱 --> 椰油酰胺丙基甜菜碱
- Sigma Aldrich:3926-62-3(sigmaaldrich)
- 毒性分级:高毒
- 爆炸物危险特性:对皮肤，角膜有腐蚀性
- 储运特性:库房通风低温干燥; 与碱类、氧化剂分开存放。
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