Dodecanoic acid 正十二烷酸

CAS 143-07-7 MFCD00002736

化学结构图

143-07-7
SMILES: CCCCCCCCCCCC(=O)O

化学属性

Mol. FormulaC12H24O2
Mol. Weight200.32
Boiling Point296.1±3.0 °C at 760 mmHg
Density0.883
Melting Point44-46 °C
Flash Point134.1±11.9 °C
TSCAYes
Vapor Pressure1 mmHg ( 121 °C)
SolubilitySoluble in water (0.5 mg/ml at 25 °C), ethanol (~20 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and chloroform.
Refractive index1.4304

别名和识别编码

Chemical NameDodecanoic acid
Synonym Lauric acid {LY} Lauric acid {} {LY} Lauric acid {} {} {LY} Lauric acid {} {} {} {LY} Lauric acid {} {} {} {} {LY} Lauric acid {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Lauric acid {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
CAS Number143-07-7
PubChem Substance ID3893
EC Number205-582-1
Beilstein Registry Number1099477
MDL NumberMFCD00002736
Reaxys-RN1099477
Merck Number5384
Chemical Name Translation正十二烷酸
Wiswesser Line NotationQV11
LabNetwork Molecule IDLN00197674
InChIInChI=1S/C12H24O2/c1-2-3-4-5-6-7-8-9-10-11-12(13)14/h2-11H2,1H3,(H,13,14)
Canonical SMILESCCCCCCCCCCCC(O)=O
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分类

  • {SA} Alphabetical Listings, Certified Food Grade Products, Flavors and Fragrances, Halal Certified Products, I-L, I-N,
  • {SNA} A-F, Acid, All Alphabetically Sorted, Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Animal Products, Biochemicals and Reagents, Chromatography, D,
  • {SNA} Alphabetical Listings, Certified Food Grade Products, Certified Natural Products, Flavors and Fragrances, Follows IFRA Guidelines, I-L, I-N, Kosher Certified Products, L-M
  • {SNA} Alphabetical Listings,

产品应用

  • A common saturated fatty acid compound.

相关文献及参考

  • Merck: 14,5384
  • Merck: 14,5384 Beilstein:2,359
  • Short: II/27B
  • Short: II/5
  • Short: III/38B
  • [1]. Nakatsuji T, et al. Antimicrobial property of lauric acid against Propionibacterium acnes: its therapeutic potential for inflammatory acne vulgaris. J Invest Dermatol. 2009 Oct;129(10):2480-8.

安全信息

WGK Germany1
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H316 Causes mild skin irritation 会轻微的刺激皮肤
  • H318 Causes serious eye damage 严重伤害眼睛
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。
Personal Protective Equipment Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
RTECSOE9800000
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P302+P352
  • P305+P351+P338
  • P305+P351+P338+P310
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P321 Specific treatment (see … on this label). 具体治疗(见本标签上的)。
  • P332+P313
  • P337+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word Danger Warning
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
Risk Statements
  • R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Hazard Codes Xi
GHS Symbol
Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 108 gm/kg/15W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - active as anti-cancer agent
REFERENCE :
   APMIAL Acta Pathologica et Microbiologica Scandinavica.  (Copenhagen,
   Denmark)  V.1-77, 1924-69.  For publisher information, see ACPADQ.
   Volume(issue)/page/year: 46,51,1959

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 131 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   APTOA6 Acta Pharmacologica et Toxicologica.  (Copenhagen, Denmark)  V.1-59,
   1945-86.  For publisher information, see PHTOEH  Volume(issue)/page/year:
   18,141,1961

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 12 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FDRLI* Food & Drug Research Laboratories, Inc., Papers.  (P.O. Box 107, Rt.
   17C, Waverly, NY 14892-0107)  Volume(issue)/page/year: 123,-,1976

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 10 mg/L
REFERENCE :
   NATUAS Nature.  (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736)
   V.1-    1869-  Volume(issue)/page/year: 294,263,1981

其他信息

  • 参考质量标准二:FCC,1996;FAO/wHO,1997 酸值(OT-4-1) 252~287 皂化值(TO-40-2,试样3g) 253~287 脂肪酸冻点(凝固点) 26~44℃ 重金属(以Pb计,GT-16-2,试样2g) ≤10mg/kg 碘值(OT-27-2) ≤3.0 不皂化物质(OT-46) ≤0.3% 水分(GT-32-1) ≤0.2% 灼烧残渣(GT-27,试样lg) ≤0.1%
  • 方法二:以甘油酯形式天然存在于椰子油、山苍子核仁油、棕榈核仁油及胡椒仁油等中。工业上可由天然油脂水解而得。将椰子油、水和催化剂加入高压釜中,在250℃、约5MPa压力下水解成甘油和脂肪酸,其中含十二烷酸达45%~80%,经蒸馏得十二烷酸。
  • {Chemical
  • 方法三:工业生产方法可归纳为两类:一是从天然植物油脂经过皂化或高温高压下分解得到;二是从合成脂肪酸中分离。日本主要以椰子油和棕榈核仁油为原料制取月桂酸。用来制取十二酸的天然植物油有:椰子油、山苍子核仁油、棕榈核仁油及山胡椒仁油等。其他植物中,如棕仁油、擦树籽油、樟树籽油等亦可服务业制取十二酸。提取十二酸所余的C12馏分,含有大量十二烯酸,可在常压加氢,不需催化剂,能以86%以上的转化率转烃为十二酸。
  • FEMA:2614
  • 用途三:我国规定可用于蔬、果脱皮,最大使用量为3.0g/kg。
  • 微有月桂油香。易溶于乙醚、苯和醇,微溶于丙酮和石油醚。1
  • 月桂酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 301088
  • 使用限量:FEMA(mg/kg):软饮料15,冷饮16,糖果2.4,焙烤食品39,布丁类25,油脂315
  • 下游产品:己酸 --> 十二醇 --> 正癸酸 --> 十八烷基二甲基叔胺 --> 十二烷基伯胺 --> 二硫化钼锂基润滑脂 --> 锂基润滑脂 --> 十二烷基二甲基叔胺 --> 月桂酸五
  • Sigma Aldr
  • {Ch
  • TCI Shanghai:月桂酸 Lauric Acid,>;98.0%(GC)(T)(143-07-7)
  • 所属类别一:食品添加剂: 食品加工助剂: 消泡剂
  • MSDS 信息:十二酸(143-07-7).msds
  • 使
  • 毒性:天然脂肪酸,无毒。 可安全用于食品(FDA,§172.860,2000)。 LD 50 12g/kg(
  • 上游原料:椰子油 --> 黑胡椒油 --> 植物油脂 --> 合成脂肪 --> 山苍子核仁油 --> 反式-2-十二烷烯酸
  • 海关编码:29159010
  • 月桂酸价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30108827 月桂酸;十二烷酸 250g 16元 2011/08/23 40028860 月桂酸;十二烷酸 5g 18元 2011/04/16 L0011 月桂酸 Lauric Acid 25G 87元
  • 下游产品:己酸 --> 十二醇 --> 正癸酸 --> 十八烷基二甲基叔胺 --> 十二烷基伯胺 --> 二硫化钼锂基润滑脂 --> 锂基润滑脂 --> 十二烷基二甲基叔胺 --> 月桂酸五氯苯酯 --> 吐温系列 --> 二月桂酸二丁基锡 --> 2-溴月桂酸 --> 脂肪酸聚氧乙烯酯 --> 月桂酰氯 --> 月桂基羟乙基羟丙基咪唑啉磺酸盐 --> 十二腈 --> 山梨糖醇酐脂肪酸酯 --> 月桂酸甲酯 --> N-月桂酰基-N'-羟乙基乙二胺丙酸盐 --> 月桂酸乙酯 --> 表面活性剂 LD-500 --> 斯盘 20 --> 十二醛 --> 栓剂基质 --> N-月桂酰基-N'-羟乙基-羧丙基乙二胺丙酸内盐
  • 参考质量标准一:FCC,1981 酸值
  • 用途二:消泡剂;GB 2760-86规定为允许使用的香料;配制其他食用级添加剂的组分。
  • Alfa Aesar:月桂酸,typically99.5% Dodecanoic acid, typically 99.
  • 微有

系列性分类


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